Single-cell transcriptomic atlas of the chicken cecum reveals cellular responses and state shifts during Eimeria tenella infection

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成果类型：

期刊论文

作者：

Tu, Jun-Hao;Liu, Bo-Gong;Lin, Bing-Jin;Liu, Hui-Chao;Guo, Song-Chang;...

通讯作者：

Song, Ze-He;Zhang, HH

作者机构：

[Liu, Bo-Gong; Lin, Bing-Jin; Guo, Song-Chang; He, Xi; Ouyang, Qing-Yuan; Song, Ze-He; Zhang, Hai-Han; Liu, Hui-Chao; Tu, Jun-Hao; Song, ZH; Zhang, HH] Hunan Agr Univ, Coll Anim Sci & Technol, Changsha, Hunan, Peoples R China.

[Guo, Song-Chang; He, Xi; Ouyang, Qing-Yuan; Song, Ze-He; Zhang, Hai-Han; Song, ZH; Zhang, HH] Xiangxi Comprehens Expt Stn Natl Chicken Ind Techn, Changde, Hunan, Peoples R China.

[Guo, Song-Chang; He, Xi; Ouyang, Qing-Yuan; Song, Ze-He; Zhang, Hai-Han; Song, ZH; Zhang, HH] Hunan Engn Res Ctr Poultry Prod Safety, Changsha, Hunan, Peoples R China.

[Guo, Song-Chang; He, Xi; Ouyang, Qing-Yuan; Song, Ze-He; Zhang, Hai-Han; Song, ZH; Zhang, HH] Yuelushan Lab, Changsha 410128, Peoples R China.

[Fang, Ling-Zhao] Aarhus Univ, Ctr Quantitat Genet & Genom, DK-8000 Aarhus, Denmark.

通讯机构：

[Song, ZH; Zhang, HH ] H

Hunan Agr Univ, Coll Anim Sci & Technol, Changsha, Hunan, Peoples R China.

Xiangxi Comprehens Expt Stn Natl Chicken Ind Techn, Changde, Hunan, Peoples R China.

Hunan Engn Res Ctr Poultry Prod Safety, Changsha, Hunan, Peoples R China.

Yuelushan Lab, Changsha 410128, Peoples R China.

语种：

英文

关键词：

Single-cell RNA sequencing (scRNA-seq);Eimeria tenella;Chicken cecum;Coccidiosis;APOB + enterocytes

期刊：

BMC Genomics

ISSN：

1471-2164

年：

2025

卷：

期：

页码：

1-11

DOI：

10.1186/s12864-025-11302-9

基金类别：

National Outstanding Youth Science Fund Project of National Natural Science Foundation of China#&#&#32302736 Supported by China Agriculture Research System of MOF and MARA#&#&#CARS-41-Z08

机构署名：

本校为第一且通讯机构

院系归属：

动物科学技术学院

摘要：

Eimeria tenella (E. tenella) infection is a major cause of coccidiosis in chickens, leading to significant economic losses in the poultry industry due to its impact on the cecum. This study presents a comprehensive single-cell atlas of the chicken cecal epithelium by generating 7,394 cells using 10X Genomics single-cell RNA sequencing (scRNA-seq). We identified 13 distinct cell types, including key immune and epithelial populations, and characterized their gene expression profiles and cell-cell communication networks. Integration of this single-cell data with bulk RNA-seq data from E. tenella-...

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Single-cell transcriptomic atlas of the chicken cecum reveals cellular responses and state shifts during Eimeria tenella infection

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