Single-Cell Transcriptome and Microbiome Profiling Uncover Ileal Immune Impairment in Intrauterine Growth-Retarded Piglets

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

He, Yiwen;Guo, Yawei;Liang, Xuqing;Hu, Hong;Xiong, Xia;...

通讯作者：

Xiong, X;Zhou, XH

作者机构：

[He, Yiwen] Hunan Normal Univ, Coll Life Sci, Hunan Prov Key Lab Anim Intestinal Funct & Regula, Changsha, Peoples R China.

[Zhou, Xihong; Liang, Xuqing; He, Yiwen; Hu, Hong; Xiong, Xia] Chinese Acad Sci, Inst Subtrop Agr, Changsha, Peoples R China.

[Guo, Yawei] Capital Med Univ, Xuanwu Hosp, Beijing 100053, Peoples R China.

[Liang, Xuqing] Hunan Agr Univ, Coll Biosci & Biotechnol, Changsha, Peoples R China.

[Hu, Hong] Hunan Agr Univ, Coll Anim Sci & Technol, Changsha, Peoples R China.

通讯机构：

[Zhou, XH ; Xiong, X ] C

Chinese Acad Sci, Inst Subtrop Agr, Changsha, Peoples R China.

Changsha Med Univ, Hunan Prov Key Lab Tradit Chinese Med Agr Biogeno, Changsha, Peoples R China.

语种：

英文

关键词：

Intrauterine growth retardation;intestine;immune cell;single-cell RNA sequencing;gut microbiota;pseudotime trajectory analysis

期刊：

CURRENT PHARMACEUTICAL DESIGN

ISSN：

1381-6128

年：

2025

卷：

页码：

1-20

DOI：

10.2174/0113816128411269250707073647

基金类别：

OE Biotech Co., Ltd (Shanghai, China)

机构署名：

本校为其他机构

院系归属：

动物科学技术学院

生物科学技术学院

摘要：

Introduction: Impaired intestinal immune function is commonly observed in neonates with intrauterine growth retardation (IUGR), yet its underlying mechanisms and regulatory pathways remain poorly understood. Therefore, we aimed to investigate gene regulatory patterns and microbiota alterations in IUGR piglets.Methods: Three newborn IUGR piglets and three normal littermates were selected from the same sow and sacrificed at seven days of age. Ileal digesta was collected for 16S rRNA amplicon sequencing (16S-seq), and ileum segments were dissociat...

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Single-Cell Transcriptome and Microbiome Profiling Uncover Ileal Immune Impairment in Intrauterine Growth-Retarded Piglets

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