期刊论文

Research on the activation and regulation mechanisms of DEG/ENaC superfamily

中文

生命科学

1004-0374

2020

32

7

723-730

10.13376/j.cbls/2020091

31971042:国家自然科学基金 2018JJ1012:湖南省自然科学基金 2018RS3086:湖南省科技厅项目 17A153:湖南省教育厅重点项目 CX2015B240:湖南省研究生科研创新项目 2018N2205:怀化市科技计划

本校为第一机构

退化蛋白/上皮钠通道(DEG/ENaC)超家族是20世纪90年代发现的一类非电压依赖性的、阿米诺利敏感的钠离子选择性离子通道,其激活方式复杂多样,参与如囊肿性纤维化、焦虑及癫痫等多种生理病理过程,已成为多种疾病的潜在药物靶标。现就DEG/ENaC超家族成员的结构、特异激活方式以及交互激活与调控机制进行综述。

Degenerin/epithelial sodium channel(DEG/ENaC)superfamily of ion channels consists of diverse members of non-voltage-gated,amiloride-sensitive,sodium-selective cation channels,and were found in the 1990s.DEG/ENaCs,with variable activation mechanisms,are involved in various physiological and pathological process,such as cystic fibrosis,anxiety and epilepsy,which makes them potential drug targets for various disease.Here,we summarize the knowledge of structure,the specific activation mechanisms,the in...