RAW264.7 mice macrophage cells cultured in vitro were induced by lipopolysaccharide （LPS） and treated with different concentration of freeze-dried powder of Ganoderma lingzhi mycelium （FDPGLM）. The differences between treating groups concerning cell viability, NO level, IL-6 level, TLR4 mRNA expression, iNOS mRNA expression, IKBa and phosphorylated NF-κB p65 protein expression were evaluated. The results showed that FDPGLM in a dose-dependent manner significantly inhibited NO production and IL-6 levels （P〈0.01）, down-regulated TLR4 mRNA...
