Effect of cytochrome P450 3A4 on tissue distribution of humantenmine, koumine, and gelsemine, three alkaloids from the toxic plant Gelsemium

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成果类型：

期刊论文

作者：

Long, Jiang-Yu;Wang, Zi-Yuan;Zuo, Meng-Ting;Huang, Si-Juan;Ma, Xiao;...

通讯作者：

Liu, ZY

作者机构：

[Wang, Zi-Yuan; Huang, Chong-Yin; Huang, Si-Juan; Qi, Xue-Jia; Long, Jiang-Yu; Liu, Zhao-Ying; Zuo, Meng-Ting; Ma, Xiao] Hunan Agr Univ, Coll Vet Med, Changsha 410128, Hunan, Peoples R China.

[Wang, Zi-Yuan; Huang, Chong-Yin; Huang, Si-Juan; Qi, Xue-Jia; Long, Jiang-Yu; Liu, Zhao-Ying; Zuo, Meng-Ting; Ma, Xiao] Hunan Agr Univ, Hunan Engn Technol Res Ctr Vet Drugs, Changsha 410128, Hunan, Peoples R China.

[Liu, Zhao-Ying] Hunan Agr Univ, Changsha 410128, Hunan, Peoples R China.

通讯机构：

[Liu, ZY ] H

Hunan Agr Univ, Changsha 410128, Hunan, Peoples R China.

语种：

英文

关键词：

Gelsemine;Gelsemium;Humantenmine;Koumine;Tissue Distribution;Toxicity

期刊：

Toxicology Letters

ISSN：

0378-4274

年：

2024

卷：

397

页码：

34-41

DOI：

10.1016/j.toxlet.2024.05.002

基金类别：

National Natural Science Foundation of China [32373072]

机构署名：

本校为第一且通讯机构

院系归属：

动物医学院

摘要：

Humantenmine, koumine, and gelsemine are three indole alkaloids found in the highly toxic plant Gelsemium. Humantenmine was the most toxic, followed by gelsemine and koumine. The aim of this study was to investigate and analyze the effects of these three substances on tissue distribution and toxicity in mice pretreated with the Cytochrome P450 3A4 (CYP3A4) inducer ketoconazole and the inhibitor rifampicin. The in vivo test results showed that the three alkaloids were absorbed rapidly and had the ability to penetrate the blood-brain barrier. At ...

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Effect of cytochrome P450 3A4 on tissue distribution of humantenmine, koumine, and gelsemine, three alkaloids from the toxic plant Gelsemium

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