RationaleGelsemium elegans (G. elegans) is highly toxic to humans and rats but has insecticidal and growth‐promoting effects on pigs and goats. However, the mechanisms behind the toxicity differences of G. elegans are unclear. Gelsenicine, isolated from G. elegans, has been reported to be a toxic alkaloid.MethodsIn this study, the in vitro metabolism of gelsenicine was investigated and compared for the first time using human (HLM), pig (PLM), goat (GLM) and rat (RLM) liver microsomes and high‐performance liquid chromatography/mass spectrometr...
