Objective To investigate the metabolic regulation mechanism of tea polyphenols and other natural antioxidants antagonizing cigarette smoke damaging HEK293 cells and its JAK2/STAT3. Methods Eight kinds of antioxidants, tea polyphenols, resveratrol, vitamin C, rutin, quercetin, chlorogenicacid, anthocyanins and proanthocyanidins, were added to cigarette filters and the smoke was collected. HEK293 cells were studied by MTT trail data and the protein expression Bcl-2, Bax, and STAT3 were analyzed by Western blot technique. Results Cigarette smoke could reduce the HEK293 cell survival rates in a do...
