Traceability of chemicals from Tripterygium Wilfordii Hook. f. in raw honey and the potential synergistic effects of honey on acute toxicity induced by celastrol and triptolide

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成果类型：

期刊论文

作者：

Xiao, Tian;Yang, Li;Yang, Fan;Nie, Guang;Jin, Xiue;...

通讯作者：

Lu, Ying;Zheng, YJ;Wang, J

作者机构：

[Zheng, Yajie; Xiao, Tian; Yang, Li; Zheng, YJ; Lu, Ying; Lu, Y; Nie, Guang] Natl Res Ctr Engn & Technol Utilizat Bot Funct Ing, Changsha 410128, Peoples R China.

[Yang, Li; Zhong, Xiaohong; Lu, Ying; Yang, Fan; Nie, Guang] Hunan Agr Univ, Coll Hort, Changsha 410128, Peoples R China.

[Wang, Jun; Jin, Xiue; Wang, J] Hubei Inst Vet Drug Control, Wuhan 430000, Peoples R China.

[Peng, Xiaoying] Hunan Agr Univ, Coll Biosci & Biotechnol, Changsha 410128, Peoples R China.

通讯机构：

[Lu, Y; Zheng, YJ ] N

[Wang, J ] H

Natl Res Ctr Engn & Technol Utilizat Bot Funct Ing, Changsha 410128, Peoples R China.

Hubei Inst Vet Drug Control, Wuhan 430000, Peoples R China.

语种：

英文

关键词：

Acute toxicity;Carboxymethylcellulose sodium (PubChem CID: 6328154);Celastrol (PubChem CID: 122724);DMSO (PubChem CID: 679);Honey;LC-MS/MS;NADES;Toxification effect;Tricaine methanesulfonate (PubChem CID: 261501);Tripterygium wilfordii Hook. f.;Triptolide (PubChem CID: 107985);Wilforgine (PubChem CID: 124030);Wilfortrine (PubChem CID: 73321);wilforine (PubChem CID: 601100)

期刊：

Food Chemistry

ISSN：

0308-8146

年：

2024

卷：

447

页码：

139044

DOI：

10.1016/j.foodchem.2024.139044

基金类别：

National Natural Science Foundation of China [31871800, 31600238]; Safety Assessment Program for Unknown Hazardous Factors and Known Hazardous Factors in Bee

机构署名：

本校为通讯机构

院系归属：

园艺园林学院

生物科学技术学院

摘要：

The object of this study was to trace TwHf-derived toxins in raw honey and clarify their acute toxic effect related to the addition of honey or sugars. TwHf flowers, raw honey from TwHf planting base and from beekeepers in high-risk area were detected using LC-MS/MS. The results revealed five target toxins were detected in TwHf flowers; only celastrol was detected in one raw honey sample, as a food safety risk factor, celastrol had been traced back to TwHf flowers from raw honey. In a series of acute toxic tests on zebrafish, toxification effects were observed when honey, mimic honey or sugar ...

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Traceability of chemicals from Tripterygium Wilfordii Hook. f. in raw honey and the potential synergistic effects of honey on acute toxicity induced by celastrol and triptolide

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