期刊论文

Studies on Screening Anti-diabetic Agonist from Momordica charantia L. by HTS

中文

天然产物研究与开发

1001-6880

2007

019

B05

26-30

本校为第一机构

PPAR与2型糖尿病存在密切关系，该受体已成为抗2型糖尿病的主要靶点。苦瓜是一种民间的中草药，药理实验文献报道具有显著的降血糖作用。本文以PPAR三种亚型PPARα、PPARγ,和PPARβ／δ为靶点的高通量筛选模型，对苦瓜多糖进行活性筛选。筛选结果表明MC-3对PPARδ和PPARγ具有较强的激活效果，其激活倍数分别达1．995、1．689。MC．3是一种潜在的降糖、降脂的活性部位。

It is found that type 2 diabetes millitus is closely related to PPAR in recent years. Therefore, PPAR is now employed as main target in developing anti-diabetes for treatment of type 2 diabetes millitus. Momordica charantia L. is a traditional Chinese medical herb. References research showed that there were some hypoglycemic active components in Momordica charantin L. Screening PPARα, β/δ,γ agonist from Momordica charantia extracts by HTS was studied in this paper. Results showed that MC-3 was an agonist of PPARγ and PPARβ/δ and the activity times were 1. 689 ...