期刊论文

中文

天然产物研究与开发

1001-6880

2008

20

3

403-407

10.3969/j.issn.1001-6880.2008.03.006

Foundation Item ：This work was supported by the National Key Project of Science and Technology in 10^th five-year Plan from the Ministry of Science and Technology （ No. 2004BA542C）. Acknowledgements The authors would like to thank Zhengying Yu and Youqun Song （Analysis Center of Hunan University） for the ^1H NMR and the MS analysis, Dr. Guorong Shi for the English modification, and Li He for the work.

本校为第一机构

本文合成了辣椒素类物质-4-O-β-D-葡萄糖苷类化合物（3）。首先，以BF3·OEt2为催化剂，用五乙酰葡萄糖酯与辣椒素类物质反应得到中间体辣椒素类物质-4-O-β-D-四乙酰葡萄糖苷类化合物（2），以硅胶柱色谱纯化收率为22%，LC-MS 分析表明含有降二氢辣椒素四乙酰葡萄糖苷（2a, M 623）、辣椒素四乙酰葡萄糖苷（2b, M 635）、二氢辣椒素四乙酰葡萄糖苷（2c, M 637）、高二氢辣椒素四乙酰葡萄糖苷（2 d, M 651）；中间体2 易水解为目标化合物3，收率63%。^1H NMR 谱分析表明化合物2及3均为β 构型。

Capsaieinoids 4-O-β-D-glucoside (3) were synthesized with an yield of 63 % by hydrolysis of capsaicinoids 4- O-β-D-tetraaetylglucoside (2) ,which was synthesized from capsaicinoids and β-D-pontaacetylglucese in the presence of BF_3·OEt_2 with an yield of 22%. LC-MS analysis showed that compound 2 contained nordihydrocapsaicin acetylglu- coside (2a,M 623) ,capsaicin acetylglucoside (2b,M 635) ,dihydrocapsaicin acetylglucoside (2c ,M 637) and homodi- hydrocapsaicin acetylglucoside (2d,M 651 ). 1H NMR sp...