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Effects of antibiotic and disinfectant exposure on the mouse gut microbiome and immune function

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成果类型:
期刊论文
作者:
Xu, Wen-Bo;Wang, Yun-Fan;Meng, Si-Yu;Zhang, Xiao-Tong;Wang, Yi-Rong;...
通讯作者:
Liu, ZY
作者机构:
[Xu, Wen-Bo; Zhang, Xiao-Tong; Wang, Yi-Rong; Wang, Yun-Fan; Liu, Zhao-Ying; Meng, Si-Yu] Hunan Agr Univ, Coll Vet Med, Changsha, Peoples R China.
[Xu, Wen-Bo; Zhang, Xiao-Tong; Wang, Yi-Rong; Wang, Yun-Fan; Liu, Zhao-Ying; Meng, Si-Yu] Hunan Agr Univ, Hunan Engn Technol Res Ctr Vet Drugs, Changsha, Peoples R China.
通讯机构:
[Liu, ZY ] H
Hunan Agr Univ, Coll Vet Med, Changsha, Peoples R China.
Hunan Agr Univ, Hunan Engn Technol Res Ctr Vet Drugs, Changsha, Peoples R China.
语种:
英文
关键词:
NLRC4;antibiotic;disinfectant;gut healthy;immunity response
期刊:
MICROBIOLOGY SPECTRUM
ISSN:
2165-0497
年:
2024
页码:
e0061124
基金类别:
Aid program for Science and Technology Innovative Research Team in Higher Educational Institutions of Hunan Province
机构署名:
本校为第一且通讯机构
院系归属:
动物医学院
摘要:
This study explores the effects of disinfectant and antibiotic exposure on gut health, focusing on gut microbiota balance and gut immune function. Our analysis indicates that disinfectants increase the proportion of Gram-positive bacteria, particularly increasing Staphylococcus levels, while antibiotics increase the proportion of Gram-negative bacteria, especially Bacteroides levels. These changes disrupt microbial harmony and affect the gut microbiome's functional capacity. Additionally, our research reveals that both disinfectants and antibiotics reduce colon length and cause mucosal damage....

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