Network Pharmacology and Experimental Verification to Unveil the Mechanism of N-Methyl-D-Aspartic Acid Rescue Humantenirine-Induced Excitotoxicity

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成果类型：

期刊论文

作者：

Qi, Xue-Jia;Huang, Chong-Yin;Zuo, Meng-Ting;Gong, Meng-Die;Huang, Si-Juan;...

通讯作者：

Zhao-Ying Liu

作者机构：

[Huang, Chong-Yin; Qi, Xue-Jia; Huang, Si-Juan; Tang, Mo-Huan; Gong, Meng-Die; Liu, Zhao-Ying; Zuo, Meng-Ting] Hunan Agr Univ, Coll Vet Med, Changsha 410128, Peoples R China.

[Huang, Chong-Yin; Qi, Xue-Jia; Huang, Si-Juan; Tang, Mo-Huan; Gong, Meng-Die; Liu, Zhao-Ying; Zuo, Meng-Ting] Hunan Agr Univ, Hunan Engn Technol Res Ctr Vet Drugs, Changsha 410128, Peoples R China.

通讯机构：

[Zhao-Ying Liu] C

College of Veterinary Medicine, Hunan Agricultural University, Changsha 410128, China<&wdkj&>Hunan Engineering Technology Research Center of Veterinary Drugs, Hunan Agricultural University, Changsha 410128, China<&wdkj&>Author to whom correspondence should be addressed.

语种：

英文

关键词：

alkaloid;mitogen activated protein kinase 1;mitogen activated protein kinase 3;n methyl dextro aspartic acid;n methyl dextro aspartic acid receptor;n methyl dextro aspartic acid receptor 2A;n methyl dextro aspartic acid receptor 2B;animal experiment;animal model;apoptosis;Article;binding affinity;calcium signaling;cell membrane;excitotoxicity;female;Gelsemium;gene ontology;hippocampal tissue;hippocampus;KEGG;LD50;long term potentiation;male;MAPK signaling;mitochondrial membrane;mitochondrial membrane potential;molecular docking;mouse;nonhuman;protein expression;protein phosphorylation;protein protein interaction;proteomics;survival rate;systems pharmacology;toxicity testing;upregulation;Western blotting

期刊：

Metabolites

ISSN：

2218-1989

年：

2023

卷：

期：

页码：

195-

DOI：

10.3390/metabo13020195

基金类别：

This research was funded by the National Natural Science Foundation of China, grant number 31972737 and the Postgraduate Scientific Research Innovation Project of Hunan Province, grant number CX20200670.

机构署名：

本校为第一机构

院系归属：

动物医学院

摘要：

Gelsemium is a medicinal plant that has been used to treat various diseases, but it is also well-known for its high toxicity. Complex alkaloids are considered the main poisonous components in Gelsemium. However, the toxic mechanism of Gelsemium remains ambiguous. In this work, network pharmacology and experimental verification were combined to systematically explore the specific mechanism of Gelsemium toxicity. The alkaloid compounds and candidate targets of Gelsemium, as well as related targets of excitotoxicity, were collected from public dat...

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Network Pharmacology and Experimental Verification to Unveil the Mechanism of N-Methyl-D-Aspartic Acid Rescue Humantenirine-Induced Excitotoxicity

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