版权说明 操作指南
首页 > 成果 > 详情

Network Pharmacology and Experimental Verification to Unveil the Mechanism of N-Methyl-D-Aspartic Acid Rescue Humantenirine-Induced Excitotoxicity

认领
导出
Link by DOI
反馈
分享
QQ微信 微博
成果类型:
期刊论文
作者:
Qi, Xue-Jia;Huang, Chong-Yin;Zuo, Meng-Ting;Gong, Meng-Die;Huang, Si-Juan;...
通讯作者:
Zhao-Ying Liu
作者机构:
[Huang, Chong-Yin; Qi, Xue-Jia; Huang, Si-Juan; Tang, Mo-Huan; Gong, Meng-Die; Liu, Zhao-Ying; Zuo, Meng-Ting] Hunan Agr Univ, Coll Vet Med, Changsha 410128, Peoples R China.
[Huang, Chong-Yin; Qi, Xue-Jia; Huang, Si-Juan; Tang, Mo-Huan; Gong, Meng-Die; Liu, Zhao-Ying; Zuo, Meng-Ting] Hunan Agr Univ, Hunan Engn Technol Res Ctr Vet Drugs, Changsha 410128, Peoples R China.
通讯机构:
[Zhao-Ying Liu] C
College of Veterinary Medicine, Hunan Agricultural University, Changsha 410128, China<&wdkj&>Hunan Engineering Technology Research Center of Veterinary Drugs, Hunan Agricultural University, Changsha 410128, China<&wdkj&>Author to whom correspondence should be addressed.
语种:
英文
关键词:
humantenirine;excitotoxicity;NMDA;NMDAR;network pharmacology;Gelsemium
期刊:
Metabolites
ISSN:
2218-1989
年:
2023
卷:
13
期:
2
页码:
195-
基金类别:
Conceptualization, Z.-Y.L.; methodology, X.-J.Q.; software, X.-J.Q.; validation, C.-Y.H., M.-T.Z. and M.-D.G.; formal analysis, X.-J.Q.; investigation, S.-J.H.; resources, Z.-Y.L.; data curation, X.-J.Q.; writing—original draft preparation, X.-J.Q.; writing—review and editing, Z.-Y.L.; visualization, M.-H.T.; supervision, Z.-Y.L.; project administration, Z.-Y.L.; funding acquisition, Z.-Y.L. All authors have read and agreed to the published version of the manuscript. This research was funded by the National Natural Science Foundation of China, grant number 31972737 and the Postgraduate Scientific Research Innovation Project of Hunan Province, grant number CX20200670.
机构署名:
本校为第一机构
院系归属:
动物医学院
摘要:
Gelsemium is a medicinal plant that has been used to treat various diseases, but it is also well-known for its high toxicity. Complex alkaloids are considered the main poisonous components in Gelsemium. However, the toxic mechanism of Gelsemium remains ambiguous. In this work, network pharmacology and experimental verification were combined to systematically explore the specific mechanism of Gelsemium toxicity. The alkaloid compounds and candidate targets of Gelsemium, as well as related targets of excitotoxicity, were collected from public databases. The crucial targets were determined by con...

反馈

验证码:
看不清楚,换一个
确定
取消

成果认领

标题:
用户 作者 通讯作者
请选择
请选择
确定
取消

提示

该栏目需要登录且有访问权限才可以访问

如果您有访问权限,请直接 登录访问

如果您没有访问权限,请联系管理员申请开通

管理员联系邮箱:yun@hnwdkj.com