期刊论文

Yuan, Zheming

英文

Medicinal Chemistry Research

1054-2523

2013

22

1

278-286

10.1007/s00044-012-0034-x

Science Foundation for Distinguished Young Scholars of Hunan Province, ChinaNational Natural Science Foundation of China (NSFC)National Science Fund for Distinguished Young Scholars [10JJ1005]; Specialized Research Fund for the Doctoral Program of Higher Education of ChinaSpecialized Research Fund for the Doctoral Program of Higher Education (SRFDP) [20114320120005]; Research Foundation of Education Bureau of Hunan Province, China [09C502]; Postgraduate Scientific Research Innovation of Hunan Province, China [CX2011B289]

本校为其他机构

ARC-111 has potent topoisomerase I-targeting activity and pronounced antitumor activity. To design ARC-111 analogues with improved efficiency, we performed analyses on the quantitative structure–activity relationship of 22 ARC-111 analogues assessed in P388 tumor cells. First, the support vector regression (SVR) models were constructed and optimized based on literature descriptors (the low-dimensional descriptor space) and the worst descriptor elimination multi-round (WDEM) method. The optimized SVR model had greater generalization ability tha...