Impaired hepatic autophagic activity in dairy cows with severe fatty liver is associated with inflammation and reduced liver function

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Du, Xiliang;Liu, Guowen;Loor, Juan J.;Fang, Zhiyuan;Bucktrout, Ryan;...

通讯作者：

Li, Xinwei

作者机构：

[Yang, Yuchen; Shi, Zhen; Peng, Zhicheng; Du, Xiliang; Ye, Qianqian; Li, Xiaobing; Zhao, Chenxu; Li, Xinwei; Shen, Taiyu; Liu, Guowen; Lv, Bin; Fang, Zhiyuan; Wang, Xinghui; Zhu, Yiwei] Jilin Univ, Coll Vet Med, Minist Educ, Key Lab Zoonosis, Changchun 130062, Jilin, Peoples R China.

[Loor, Juan J.; Bucktrout, Ryan] Univ Illinois, Dept Anim Sci, Mammalian NutriPhysioGen, Urbana, IL 61801 USA.

[Loor, Juan J.; Bucktrout, Ryan] Univ Illinois, Div Nutr Sci, Urbana, IL 61801 USA.

[Xing, Dongmei] Hunan Agr Univ, Anim Med Coll, Changsha 410128, Hunan, Peoples R China.

通讯机构：

[Li, Xinwei] J

Jilin Univ, Coll Vet Med, Minist Educ, Key Lab Zoonosis, Changchun 130062, Jilin, Peoples R China.

语种：

英文

关键词：

liver lipidosis;autophagy;lactation;inflammation

期刊：

Journal of Dairy Science

ISSN：

0022-0302

年：

2018

卷：

101

期：

页码：

11175-11185

DOI：

10.3168/jds.2018-15120

基金类别：

National Key Research and Development Program (Beijing, China) [2016YFD0501206]; National Natural Science Foundation of China (Beijing, China)National Natural Science Foundation of China (NSFC) [31472247, 31572581, 31672621, 31772810]; Jilin Province Science Foundation for Youths (Chang-chun, China) [20160520063JH]; Jilin Natural Science Foundation (Chang-chun, China) [20170101148JC]

机构署名：

本校为其他机构

院系归属：

动物医学院

摘要：

The ability of liver to respond to changes in nutrient availability is essential for the maintenance of metabolic homeostasis. Autophagy encompasses mechanisms of cell survival, including capturing, degrading, and recycling of intracellular proteins and organelles in lysosomes. During negative nutrient status, autophagy provides substrates to sustain cellular metabolism and hence, tissue function. Severe negative energy balance in dairy cows is associated with fatty liver. The aim of this study was to investigate the hepatic autophagy status in dairy cows with severe fatty liver and to deter- ...

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Impaired hepatic autophagic activity in dairy cows with severe fatty liver is associated with inflammation and reduced liver function

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