Inhibition of cytochrome P450 2A participating in coumarin 7-hydroxylation in pig liver microsomes

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成果类型：

期刊论文

作者：

Liu, Z. -Y.;Dai, M. -H.;Tao, Y. -F.;Chen, D. -M.;Yuan, Z. -H.*

通讯作者：

Yuan, Z. -H.

作者机构：

[Liu, Z. -Y.] Huazhong Agr Univ, Coll Vet Med, MAO Key Lab Food Safety Evaluat, Natl Reference Lab Vet Drug Residues HZAU, Wuhan 430070, Hubei, Peoples R China.

[Liu, Z. -Y.] Hunan Agr Univ, Fac Vet, Changsha, Hunan, Peoples R China.

[Yuan, Z. -H.] Huazhong Agr Univ, Coll Vet Med, MAO Key Lab Food Safety Evaluat, Natl Reference Lab Vet Drug Residues HZAU, Shizishan St, Wuhan 430070, Hubei, Peoples R China.

通讯机构：

[Yuan, Z. -H.] H

Huazhong Agr Univ, Coll Vet Med, MAO Key Lab Food Safety Evaluat, Natl Reference Lab Vet Drug Residues HZAU, Shizishan St, Wuhan 430070, Hubei, Peoples R China.

语种：

英文

期刊：

Journal of Veterinary Pharmacology and Therapeutics

ISSN：

0140-7783

年：

2011

卷：

期：

页码：

424-429

DOI：

10.1111/j.1365-2885.2010.01262.x

机构署名：

本校为其他机构

院系归属：

动物医学院

摘要：

Liu, Z.‐Y., Dai, M.‐H., Tao, Y.‐F., Chen, D.‐M., Yuan, Z.‐H. Inhibition of cytochrome P450 2A participating in coumarin 7‐hydroxylation in pig liver microsomes. J. vet. Pharmacol. Therap. 34, 424–429. Five commonly used human cytochrome P450 (CYP) inhibitors were examined for their effects on coumarin 7‐hydroxylase (CYP2A) activity in pig liver microsomes. The K m and V max values for coumarin 7‐hydroxylation in pig liver microsomes were estimated to be 1 μm and 0.26 nmol·mg/min, respectively. The following human CYP inhibitors cau...

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Inhibition of cytochrome P450 2A participating in coumarin 7-hydroxylation in pig liver microsomes

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