To optimize the fermentation medium of microbial,a novel culture medium optimization method based on uniform de-sign (UD)and support vector regression (SVR)is proposed.Firstly,a composition with fewer schemes is designed by UD meth-od according to the primal formula,and then the prediction based on SVR is carried out after kernel optimization and descriptors screening.The results which have predicted values higher than threshold are analyzed by factor’s frequency statistics.The opti-mization process is iterated to obtain the target result.This...