期刊论文

英文

FRONTIERS IN IMMUNOLOGY

1664-3224

2023

14

1162208

10.3389/fimmu.2023.1162208

This study was supported by grants from the Natural Science Foundation of Hubei Province of China (2022CFB564), the Health Commission Foundation of Hubei Province of China (WJ2023M108), the Open project of National Virus Resource Center (NVRC-PY-03), Sino-German mobility programme (M-0060), Traditional Chinese Medicine Administration Foundation of Hubei Province of China (ZY2023F027) and the Young and Middle-aged Medical Professionals in Wuhan (grant number 1030000301). This work was also supported by the International Cooperation Base of Hubei Province for Infection and Immunity.

本校为其他机构

Among enteroviruses, echovirus can cause severe illnesses in neonates or infants, with high morbidity and mortality. Autophagy, a central component of host defense mechanisms, can function against diverse infections. In the present study, we investigated the interplay between echovirus and autophagy. We demonstrated that echovirus infection increases LC3-II expression dose-dependently, accompanied by an increased intracellular LC3 puncta level. In addition, echovirus infection induces the formation of autophagosome. These results suggest that echovirus infection induces autophagy machinery. Fu...