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IRW and IQW Reduce Colitis-Associated Cancer Risk by Alleviating DSS-Induced Colonic Inflammation

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成果类型:
期刊论文
作者:
Ma, Yong;Jiang, Hongmei*;Fang, Jun*;Liu, Gang
通讯作者:
Jiang, Hongmei;Fang, Jun
作者机构:
[Liu, Gang; Jiang, Hongmei; Fang, Jun; Ma, Yong] Hunan Agr Univ, Coll Biosci & Biotechnol, Coll Anim Sci & Technol, Changsha 410128, Hunan, Peoples R China.
[Liu, Gang] Chinese Acad Sci, Natl Engn Lab Pollut Control & Waste Utilizat Liv, Key Lab Anim Nutr Physiol & Metab Proc, Key Lab Agroecol Proc Subtrop Reg,Inst Subtrop Ag, Changsha 410125, Hunan, Peoples R China.
通讯机构:
[Jiang, HM; Fang, J] H
Hunan Agr Univ, Coll Biosci & Biotechnol, Coll Anim Sci & Technol, Changsha 410128, Hunan, Peoples R China.
语种:
英文
期刊:
BioMed Research International
ISSN:
2314-6133
年:
2019
卷:
2019
基金类别:
National Natural Science Foundation of ChinaNational Natural Science Foundation of China [31672457, 31772642]; Ministry of Agricultural of the People's Republic of China [2015-Z64, 2016-X47]; Hunan Provincial Science and Technology Department [2016NK2101, 2017NK2322, 2016WK2008, 2016TP2005]; Double First-Class Construction Project of Hunan Agricultural University [SYL201802003]; China Postdoctoral Science FoundationChina Postdoctoral Science Foundation [2018M632963, 2019T120705]; Local Science and Technology Development Project [YDZX20184300002303]
机构署名:
本校为第一且通讯机构
院系归属:
动物科学技术学院
生物科学技术学院
摘要:
Background and Objective. Bioactive peptides exert great influence in animals and human health by targeting gastrointestinal tracts. The colitis model of mice was induced by dextran sulfate sodium (DSS). Thirty-two 8-week-old mice weighing 23 g on average were randomly assigned to four groups of 8 each: Mice fed basal diet (CON), mice fed basal diet with 5% DSS (DSS), mice fed 0.03% IRW with 5% DSS (IRW-DSS), and mice fed 0.03% IRW with 5% DSS (IQW-DSS). After an adaptation period of 3 days, on day 8, all mice were slaughtered. Serum samples we...

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