Phosphorylation of nucleolin is indispensable to upregulate miR-21 and inhibit apoptosis in cardiomyocytes

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成果类型：

期刊论文

作者：

Tong, Zhongyi;Tang, Yuting;Jiang, Bimei*;Wu, Yanyang;Liu, Yanjuan;...

通讯作者：

Jiang, Bimei

作者机构：

[Xiao, Xianzhong; Li, Yuanbin; Tong, Zhongyi; Liu, Yanjuan; Jiang, Bimei; Tang, Yuting] Cent S Univ, Xiangya Sch Med, Dept Pathophysiol, Changsha, Hunan, Peoples R China.

[Tong, Zhongyi] Cent S Univ, Xiangya Hosp 2, Dept Pathol, Changsha, Hunan, Peoples R China.

[Wu, Yanyang] Hunan Agr Univ, Food Sci & Technol Coll, Dept Microbiol, Changsha, Hunan, Peoples R China.

通讯机构：

[Jiang, Bimei] C

Cent S Univ, Xiangya Sch Med, Dept Pathophysiol, Changsha, Hunan, Peoples R China.

语种：

英文

关键词：

alanine;hydrogen peroxide;microRNA 21;nucleolin;threonine;Ago2 protein, rat;argonaute protein;hydrogen peroxide;microRNA;MIRN21 microRNA, mouse;mirn21 microRNA, rat;nucleolin;phosphoprotein;RNA binding protein;animal cell culture;animal experiment;animal model;apoptosis;Article;cardiac muscle cell;cardiac myoblast;cell protection;H9c2(2-1) cell line;in vitro study;in vivo study;male;myocardial ischemia reperfusion injury;nonhuman;oxidative stress;priority journal;protein expression;protein glycosylation;protein phosphorylation;protein processing;rat;site directed mutagenesis;animal;Bagg albino mouse;cardiac muscle cell;cell line;disease model;drug effect;genetics;metabolism;mutation;pathology;phosphorylation;signal transduction;upregulation;Animals;Apoptosis;Argonaute Proteins;Cell Line;Disease Models, Animal;Hydrogen Peroxide;Male;Mice, Inbred BALB C;MicroRNAs;Mutation;Myocardial Reperfusion Injury;Myocytes, Cardiac;Oxidative Stress;Phosphoproteins;Phosphorylation;Rats;RNA-Binding Proteins;Signal Transduction;Up-Regulation

期刊：

JOURNAL OF CELLULAR PHYSIOLOGY

ISSN：

0021-9541

年：

2019

卷：

234

期：

页码：

4044-4053

DOI：

10.1002/jcp.27191

基金类别：

National Natural Science Foundation of China, Grant/Award Numbers: 81501708, 81220279, 81370252, 81770306, 81471868; Province Natural Science Foundation of Hunan, Grant/Award Number: 2018JJ2547 This study was supported by funding from the National Natural Science Foundation of China, Grant/Award Numbers: 81501708, 81220279, 81370252, 81770306, 81471868；Province Natural Science Foundation of Hunan, Grant/Award Number: 2018JJ2547. The authors are thankful to professor Michael B. Kastan (St. Jude Children’s Research Hospital, USA) for his gift of nucleolin plasmid. This study was supported by funding from the National Natural Science Foundation of China, Grant/Award Numbers: 81501708, 81220279, 81370252, 81770306, 81471868; Province Natural Science Foundation of Hunan, Grant/Award Number: 2018JJ2547. The authors are thankful to professor Michael B. Kastan (St. Jude Children?s Research Hospital, USA) for his gift of nucleolin plasmid.

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本校为其他机构

院系归属：

食品科学技术学院

摘要：

Nucleolin is a multifunctional phosphoprotein and is involved in protecting from myocardial ischemia/reperfusion (I/R) injury. The function of nucleolin is regulated by posttranslational modifications, including phosphorylation and glycosylation. To study whether phosphorylation of nucleolin (P-nucleolin) was involved in the protection from myocardial I/R injury. We investigated the expression pattern of P-nucleolin (Thr-76 and 84) in hearts subjected to I/R injury, or rat cardiac myoblast cells (H9C2) subjected to hydrogen peroxide (H 2 O 2 )....

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Phosphorylation of nucleolin is indispensable to upregulate miR-21 and inhibit apoptosis in cardiomyocytes

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