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Phosphorylation of nucleolin is indispensable to upregulate miR-21 and inhibit apoptosis in cardiomyocytes

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成果类型:
期刊论文
作者:
Tong, Zhongyi;Tang, Yuting;Jiang, Bimei*;Wu, Yanyang;Liu, Yanjuan;...
通讯作者:
Jiang, Bimei
作者机构:
[Xiao, Xianzhong; Li, Yuanbin; Tong, Zhongyi; Liu, Yanjuan; Jiang, Bimei; Tang, Yuting] Cent S Univ, Xiangya Sch Med, Dept Pathophysiol, Changsha, Hunan, Peoples R China.
[Tong, Zhongyi] Cent S Univ, Xiangya Hosp 2, Dept Pathol, Changsha, Hunan, Peoples R China.
[Wu, Yanyang] Hunan Agr Univ, Food Sci & Technol Coll, Dept Microbiol, Changsha, Hunan, Peoples R China.
通讯机构:
[Jiang, Bimei] C
Cent S Univ, Xiangya Sch Med, Dept Pathophysiol, Changsha, Hunan, Peoples R China.
语种:
英文
关键词:
ago2;miR-21;myocardial ischemia reperfusion injury;nucleolin;phosphorylation
期刊:
JOURNAL OF CELLULAR PHYSIOLOGY
ISSN:
0021-9541
年:
2019
卷:
234
期:
4
页码:
4044-4053
基金类别:
National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81501708, 81220279, 81370252, 81770306, 81471868]; Province Natural Science Foundation of Hunan [2018JJ2547]
机构署名:
本校为其他机构
院系归属:
食品科学技术学院
摘要:
Nucleolin is a multifunctional phosphoprotein and is involved in protecting from myocardial ischemia/reperfusion (I/R) injury. The function of nucleolin is regulated by posttranslational modifications, including phosphorylation and glycosylation. To study whether phosphorylation of nucleolin (P-nucleolin) was involved in the protection from myocardial I/R injury. We investigated the expression pattern of P-nucleolin (Thr-76 and 84) in hearts subjected to I/R injury, or rat cardiac myoblast cells (H9C2) subjected to hydrogen peroxide (H 2 O 2 ). The results showed that the expression of P-nucle...

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