The Genome of Medicinal Plant Macleaya cordata Provides New Insights into Benzylisoquinoline Alkaloids Metabolism

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成果类型：

期刊论文

作者：

Liu, Xiubin;Liu, Yisong;Huang, Peng;Ma, Yongshuo;Qing, Zhixing;...

通讯作者：

Zeng, Jianguo;Xiong, Xingyao;Shang, Yi;Huang, Sanwen

作者机构：

[Liu, Xiubin; Zheng, Yajie; Liu, Yisong; Zeng, Jianguo; Tang, Qi; Cheng, Pi; Huang, Peng] Hunan Agr Univ, Natl & Local Union Engn Res Ctr Vet Herbal Med Re, Changsha 410128, Hunan, Peoples R China.

[Liu, Xiubin; Zheng, Yajie; Liu, Yisong; Zeng, Jianguo; Tang, Qi; Cheng, Pi; Qing, Zhixing; Huang, Peng] Hunan Agr Univ, Hunan Coinnovat Ctr Utilizat Bot Funct Ingredient, Changsha 410128, Hunan, Peoples R China.

[Liu, Xiubin; Liu, Jinfeng; Zheng, Yajie; Yu, Linlan; Zeng, Jianguo; Xiong, Xingyao; Tang, Qi; Cheng, Pi; Zhuo, Yixiu; Huang, Peng] Hunan Agr Univ, Hort & Landscape Coll, Changsha 410128, Hunan, Peoples R China.

[Huang, Jialu; Liu, Yisong] Hunan Agr Univ, Vet Med Coll, Changsha 410128, Hunan, Peoples R China.

[Huang, Sanwen; Shang, Yi; Huang, SW; Zhang, Zhonghua; Zhou, Yuan; Ma, Yongshuo] Chinese Acad Agr Sci, Sinodutch Joint Lab Hort Genom, Key Lab Biol & Genet Improvement Hort Crops, Inst Vegetables & Flowers,Minist Agr, Beijing 100081, Peoples R China.

通讯机构：

[Zeng, Jianguo; Xiong, XY; Zeng, JG] H

[Shang, Y; Huang, SW] C

Hunan Agr Univ, Natl & Local Union Engn Res Ctr Vet Herbal Med Re, Changsha 410128, Hunan, Peoples R China.

Hunan Agr Univ, Hunan Coinnovat Ctr Utilizat Bot Funct Ingredient, Changsha 410128, Hunan, Peoples R China.

Hunan Agr Univ, Hort & Landscape Coll, Changsha 410128, Hunan, Peoples R China.

语种：

英文

关键词：

Macleaya cordata genome;Benzylisoquinoline alkaloids;Secondary metabolism;Sanguinarine;Chelerythrine;Isotopic labeling

关键词(中文)：

动物农业;公共卫生;转基因;生物碱

期刊：

分子植物

ISSN：

1674-2052

年：

2017

卷：

期：

页码：

975-989

DOI：

10.1016/j.molp.2017.05.007

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [31200615, 31600238]; Postgraduate Research and Innovation Project of Hunan Province [CX2014B302]; National Key Laboratory Cultivation Base Construction Project [15KFXM09]; National Science-Technology Support Plan Projects of China [2012BAI29B04]; The talent introduction Science Foundation of Hunan Agricultural University [13YJ09]; Natural Science Foundation of Hunan ProvinceNatural Science Foundation of Hunan Province [2016JJ4040]

机构署名：

本校为第一且通讯机构

院系归属：

园艺园林学院

摘要：

The overuse of antibiotics in animal agriculture and medicine has caused a series of potential threats to public health. Macleaya cordata is a medicinal plant species from the Papaveraceae family, providing a safe resource for the manufacture of antimicrobial feed additive for livestock. The active constituents from M. cordata are known to include benzylisoquinoline alkaloids (BIAs) such as sanguinarine (SAN) and chelerythrine (CHE), but their metabolic pathways have yet to be studied in this non-model plant. The active biosynthesis of SAN and ...

摘要(中文)：

在动物农业和药的抗菌素的 overuse 引起了一系列潜在的威胁到公共健康。Macleaya cordata 是从 Papaveraceae 家庭的药用的植物种，提供为抗菌剂的制造的一个安全资源为家畜喂添加剂。从 M. 的活跃成分 ? cordata 被知道包括 benzylisoquinoline 碱(偏爱) 象 sanguinarine (圣) 和 chelerythrine (CHE ) 那样的 ?，而是他们的新陈代谢的小径还得在这非模型植物被学习。在 M. 的圣和 CHE 的活跃生合成 ? cordata 被喂 13标记 C 的酷氨酸。为了增加，推进卓见，我们 de novo 定序 M 的整个染色体。cordata，第一从 Papaveraceae 家庭被定序。M.? 盖住 378 Mb 的 cordata 染色体与 43.5%being 编码...

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The Genome of Medicinal Plant Macleaya cordata Provides New Insights into Benzylisoquinoline Alkaloids Metabolism

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