Cucumber (Cucumis sativus) is one of the model plants for sexual studies. Sex determination of cucumber is of great significance for the increase of bear fruit yield from female flowers. Researches suggest that sex in cucumber plant is modified by sex determination genes, environmental conditions and plant hormones. This paper reviews recent advances relating to sex determination in cucumber, and outlooks the developmental mechanism of unisexual flower and spatiotemporal expression of sex-determining ge...