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New acylglycosides flavones from Fuzhuan brick tea and simulation analysis of their bioactive effects

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成果类型:
期刊论文
作者:
Lu, Ying;He, Yingjie;Zhu, Shihao;Zhong, Xiaohong;Chen, Dong*;...
通讯作者:
Liu, Zhonghua;Chen, Dong
作者机构:
[Lu, Ying; He, Yingjie; Zhu, Shihao; Liu, Zhonghua] Hunan Agr Univ, Natl Res Ctr Engn Technol Utilizat Funct Ingredie, Changsha 410128, Hunan, Peoples R China.
[Zhong, Xiaohong; Lu, Ying; He, Yingjie; Zhu, Shihao; Liu, Zhonghua] Hunan Agr Univ, Hort & Landscape Coll, Changsha 410128, Hunan, Peoples R China.
[Chen, Dong] Guangdong Acad Agr Sci, Drinkable Plant Res Inst, Tea Res Ctr, Guangzhou 510000, Guangdong, Peoples R China.
通讯机构:
[Liu, Zhonghua] H
[Chen, Dong] G
Hunan Agr Univ, Natl Res Ctr Engn Technol Utilizat Funct Ingredie, Changsha 410128, Hunan, Peoples R China.
Hunan Agr Univ, Hort & Landscape Coll, Changsha 410128, Hunan, Peoples R China.
Guangdong Acad Agr Sci, Drinkable Plant Res Inst, Tea Res Ctr, Guangzhou 510000, Guangdong, Peoples R China.
语种:
英文
关键词:
acylglycoside flavone;flavone;glycoside;hydroxymethylglutaryl coenzyme A reductase;kaempferol;quercetin;unclassified drug;3-hydroxy-3-methylglutaryl-coenzyme A;acyl coenzyme A;glucosidase;glycoside;kaempferol derivative;protein binding;quercetin;antidiabetic activity;Article;biological activity;carbon nuclear magnetic resonance;chemical structure;cluster analysis;fuzhuan brick tea;high performance liquid chromatography;human;hypoglycemia;hypolipemia;hypolipidemic activity;metabolite;molecular docking;proton nuclear magnetic resonance;simulation;tea;time of flight mass spectrometry;analogs and derivatives;Camellia sinensis;chemistry;metabolism;molecular docking;tea;Acyl Coenzyme A;Camellia sinensis;Glucosidases;Glycosides;Humans;Kaempferols;Molecular Docking Simulation;Protein Binding;Quercetin;Tea
期刊:
International Journal of Molecular Sciences
ISSN:
1661-6596
年:
2019
卷:
20
期:
3
页码:
494
基金类别:
Hunan Provincial Department of Education [15A088]; Hunan Natural Science FoundationNatural Science Foundation of Hunan Province [2018JJ2174]; Project of Hunan Postgraduate Research and Innovation [CX2016B311]
机构署名:
本校为第一且通讯机构
院系归属:
园艺园林学院
摘要:
Four novel acylglycosides flavones (AGFs) including two quercetin acylglycosides and two kaempferol acylglycosides were isolated from Fuzhuan brick tea (FBT) as follows: quercetin 3-O-[alpha-l-rhamnopyranosyl (1-->3)] [2-O''-(E)-p-coumaroyl] [beta-d-glucopyranosyl (1-->3)-alpha-l-rhamnopyranosyl (1-->6)]-beta-d-galactoside was named as camelliquercetiside E (1), quercetin 3-O-[alpha-l-rhamnopyranosyl (1-->3)] [2-O''-(E)-p-coumaroyl] [alpha-l-rhamnopyranosyl (1-->6)]-beta-d-galactoside was named as camelliquercetiside F (2), kaempferol 3-O-[alpha-l-arabinopyranosyl (1-->3)] [2-O''-(E)-p-coumaro...

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