The TERT rs2736100 polymorphism increases cancer risk: A meta-analysis

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成果类型：

期刊论文

作者：

Li, Hui;Xu, Yanyan;Mei, Hua;Peng, Liang;Li, Xiaojie;...

通讯作者：

Tang, Jianzhou

作者机构：

[Li, Hui] Jishou Univ, Med Sch, Dept Microbiol & Immunol, Jishou 416000, Hunan, Peoples R China.

[Xu, Yanyan] Guangzhou Kingmed Ctr Clin Lab, Dept Mol Pathol, Guangzhou 510000, Guangdong, Peoples R China.

[Mei, Hua] Hunan Guangxiu Hosp, Dept Somat Stem Cell, Changsha 410002, Hunan, Peoples R China.

[Peng, Liang; Tang, Jianzhou] Changsha Univ, Dept Biol & Environm Engn, Changsha 410003, Hunan, Peoples R China.

[Tang, Jianzhou; Li, Xiaojie] Hunan Agr Univ, Coll Anim Sci & Technol, Changsha 410128, Hunan, Peoples R China.

通讯机构：

[Tang, Jianzhou] C

[Tang, Jianzhou] H

Changsha Univ, Dept Biol & Environm Engn, Changsha 410003, Hunan, Peoples R China.

Hunan Agr Univ, Coll Anim Sci & Technol, Changsha 410128, Hunan, Peoples R China.

语种：

英文

关键词：

TERT;cancer;meta-analysis;risk;telomerase

期刊：

Oncotarget

ISSN：

1949-2553

年：

2017

卷：

期：

页码：

38693-38705

DOI：

10.18632/oncotarget.16309

机构署名：

本校为通讯机构

院系归属：

动物科学技术学院

摘要：

Abnormal telomerase activity is implicated in cancer initiation and development. The rs2736100 T > G polymorphism in the telomerase reverse transcriptase (TERT) gene, which encodes the telomerase catalytic subunit, has been associated with increased cancer risk. We conducted a meta-analysis to more precisely assess this association. After a comprehensive literature search of the PubMed and EMBASE databases up to November 1, 2016, 61 articles with 72 studies comprising 108,248 cases and 161,472 controls were included in our meta-analysis. Studies were conducted on various cancer types. The TERT...

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The TERT rs2736100 polymorphism increases cancer risk: A meta-analysis

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