期刊论文

Research Advances in Structure and Function of Transmembrane Protein CD 2v of African Swine Fever Virus

中文

病毒学报

1000-8721

2021

37

05

1244-1251

10.13242/j.cnki.bingduxuebao.004023

湖南省重点领域研发计划（项目号：2019NK2171），题目：非洲猪瘟精准、高灵敏和超快速检测新技术的创制及应用~~；

本校为第一机构

非洲猪瘟（African swine fever,ASF）是由非洲猪瘟病毒（African swine fever virus,ASFV）感染家猪和野猪,引起的高度传染性和致死性动物传染病,不同品种和年龄阶段的猪均易感,发病率和死亡率可高达100%。ASFV是全球生猪产业的重点疫病之一,目前无商品化疫苗。ASFV是一种大而复杂的双链DNA双层囊膜病毒。ASFV主要跨膜蛋白CD2v是介导血细胞吸附（Hemadsorption,HAD）和鉴定病毒血清型的关键蛋白,它参与ASFV宿主免疫应答、免疫逃逸和病毒复制等生理生化过程,且是ASFV疫苗和抗病毒分子研发的潜在重要靶点。探究CD2v在ASFV感染中的作用及机制渐成热点。因此,本文对ASFV CD2v的结构及其生物学功能研...

African swine fever(ASF)is an acute inflammatory animal infectious disease in domestic pigs and wild pigs infected by African swine fever virus(ASFV). Different breeds and all age of swine are susceptible to ASFV infection,and the rate of morbidity and mortality from ASFV infection can be up to 100%. ASFV is one of the major diseases in global pig industry,but no commercial vaccine is available. The ASFV is a large, complex,double-stranded DNA double-enveloped virus. CD2v is a main transmembrane protein of the ASFV that mediates hemadsorption,and has been used to identify the ASFV serotype as ...