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Dual recognition element-controlled logic DNA circuit for COVID-19 detection based on exonuclease III and DNAzyme

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成果类型:
期刊论文
作者:
Pan, Jiafeng;He, Ying;Liu, Zhi*;Chen, Junhua*
通讯作者:
Liu, Zhi;Chen, Junhua
作者机构:
[Liu, Zhi; He, Ying; Pan, Jiafeng] Hunan Agr Univ, Coll Biosci & Biotechnol, Changsha 410128, Peoples R China.
[Chen, Junhua] Guangdong Acad Sci, Inst Ecoenvironm & Soil Sci, Guangdong Key Lab Integrated Agrornvironm Pollut, Natl Reg Joint Engn Res Ctr Soil Pollut Control &, Guangzhou 510650, Peoples R China.
通讯机构:
[Liu, Zhi] H
[Chen, Junhua] G
Hunan Agr Univ, Coll Biosci & Biotechnol, Changsha 410128, Peoples R China.
Guangdong Acad Sci, Inst Ecoenvironm & Soil Sci, Guangdong Key Lab Integrated Agrornvironm Pollut, Natl Reg Joint Engn Res Ctr Soil Pollut Control &, Guangzhou 510650, Peoples R China.
语种:
英文
期刊:
Chemical Communications
ISSN:
1359-7345
年:
2021
卷:
57
期:
9
页码:
1125-1128
基金类别:
Provincial Excellent Doctoral Dissertation Cultivation Fund of Hunan Agricultural University [YB2019001]; Graduate Student Research Innovation Project of Hunan Province [CX20200654]
机构署名:
本校为第一且通讯机构
院系归属:
生物科学技术学院
摘要:
Two fragments of the COVID-19 genome (specific and homologous) were used as two inputs to construct an AND logic gate for COVID-19 detection based on exonuclease III and DNAzyme. The detection sensitivity of the assay can reach fM levels. Satisfactory recovery value...

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