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Porcine Parvovirus 7: Evolutionary Dynamics and Identification of Epitopes toward Vaccine Design

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成果类型:
期刊论文
作者:
Wang, Dongliang;Mai, Jinhui;Yang, Yi;Wang, Naidong*
通讯作者:
Wang, Naidong
作者机构:
[Wang, Naidong; Wang, Dongliang; Mai, Jinhui; Yang, Yi] Hunan Agr Univ, Hunan Prov Key Lab Prot Engn Anim Vaccines, Lab Funct Prote LFP, Res Ctr Reverse Vaccinol RCRV,Coll Vet Med, Changsha 410128, Peoples R China.
通讯机构:
[Wang, Naidong] H
Hunan Agr Univ, Hunan Prov Key Lab Prot Engn Anim Vaccines, Lab Funct Prote LFP, Res Ctr Reverse Vaccinol RCRV,Coll Vet Med, Changsha 410128, Peoples R China.
语种:
英文
关键词:
PPV7;Cap;B cell and T cell epitopes;vaccine;evolution
期刊:
Vaccines
ISSN:
2076-393X
年:
2020
卷:
8
期:
3
页码:
359-
基金类别:
Conceptualization, D.W., N.W.; methodology, D.W., J.M.; software, D.W., J.M.; validation, D.W., J.M.; formal analysis, D.W., J.M.; investigation, D.W.; resources, D.W.; data curation, D.W.; writing—original draft preparation, D.W., N.W.; writing—review and editing, N.W., Y.Y.; visualization, D.W.; supervision, N.W., Y.Y.; project administration, N.W., Y.Y.; funding acquisition, D.W., N.W. All authors have read and agreed to the published version of the manuscript. This research was funded by Hunan Provincial Natural Science Foundation of China, grant number 2018JJ2177; Double first-class construction project of Hunan Agricultural University, grant number SYL2019048 and Postgraduate Research and Innovation Project of Hunan Province, grant number CX2018B394.
机构署名:
本校为第一且通讯机构
院系归属:
动物医学院
摘要:
Porcine parvovirus 7 (PPV7) belonging to the genus Chapparvovirus in the family Parvoviridae, has been identified in the USA, Sweden, Poland, China, South Korea and Brazil. Our objective was to determine the phylogeny, estimate the time of origin and evolutionary dynamics of PPV7, and use computer-based immune-informatics to assess potential epitopes of its Cap, the main antigenic viral protein, for vaccines or serology. Regarding evolutionary dynamics, PPV7 had 2 major clades, both of which possibly had a common ancestor in 2004. Furthermore, ...

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