Protection of capsaicin against hypoxia-reoxygenation-induced apoptosis of rat hippocampal neurons

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成果类型：

期刊论文

作者：

Guo, Shi-Yin;Yang, Guo-Ping;Jiang, De-Jian;Wang, Feng;Song, Tao;...

通讯作者：

Sun, Zhen-Qiu

作者机构：

[Guo, Shi-Yin; Sun, Zhen-Qiu; Wang, Feng] Cent S Univ, Sch Publ Hlth, Changsha 410078, Peoples R China.

[Tan, Xing-He; Guo, Shi-Yin] Hunan Agr Univ, Fac Food Sci & Technol, Changsha, Peoples R China.

[Yang, Guo-Ping] Cent S Univ, Xiangya Hosp 3, Ctr Clin Pharmacol, Changsha 410078, Peoples R China.

[Song, Tao; Jiang, De-Jian] Cent S Univ, Sch Pharmaceut Sci, Dept Pharmacol, Changsha 410078, Peoples R China.

[Sun, Zhen-Qiu] Cent S Univ, Sch Publ Hlth, Xiang Ya Rd 110, Changsha 410078, Peoples R China.

通讯机构：

[Sun, Zhen-Qiu] C

Cent S Univ, Sch Publ Hlth, Xiang Ya Rd 110, Changsha 410078, Peoples R China.

语种：

英文

关键词：

capsaicin;apoptosis;hypoxia–reoxygenation;hippocampal neurons;PI3K/Akt;capsaïcine;apoptose;hypoxie/réoxygénation;neurones hippocampiques;PI3K/Akt

期刊：

CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY

ISSN：

0008-4212

年：

2008

卷：

期：

页码：

785-792

DOI：

10.1139/Y08-083

基金类别：

Ministry of Agriculture, China [2003-T18]

机构署名：

本校为其他机构

院系归属：

食品科学技术学院

摘要：

The aim of this study was to investigate the effect of capsaicin on hypoxia-reoxygenation (H/R)-induced apoptosis in primary rat hippocampal neurons. Three hours of hypoxia (1% O2) and subsequent reoxygenation for 24 h significantly increased the apoptotic death of hippocampal neurons, as evidenced by increases in both TUNEL-positive cell number and caspase-3 activity. Pretreatment with capsaicin (3-30 micromol/L) or the caspase-3-specific inhibitor acetyl-DEVD-CHO (100 micromol/L) markedly attenuated H/R-induced apoptosis in hippocampal neurons. Capsaicin also markedly induced the phosphoryla...

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Protection of capsaicin against hypoxia-reoxygenation-induced apoptosis of rat hippocampal neurons

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