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Role and Mechanism of Theaflavins in Regulating Skeletal Muscle Inflammation

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成果类型:
期刊论文
作者:
Liu, Changwei;Liu, Ailing;Zhou, Jinghui;Zhang, Yangbo;Zhou, Fang;...
通讯作者:
Sheng Zhang<&wdkj&>Jianan Huang<&wdkj&>Zhonghua Liu
作者机构:
[Zhang, Yangbo; Liu, Changwei; Liu, Zhonghua; Zhang, Sheng; Zhou, Jinghui; Huang, Jianan; Chen, Hongyu; Zhou, Fang; Liu, Qi] Hunan Agr Univ, Key Lab Tea Sci, Minist Educ, Changsha 410128, Hunan, Peoples R China.
[Zhang, Yangbo; Liu, Changwei; Liu, Zhonghua; Zhang, Sheng; Zhou, Jinghui; Huang, Jianan; Chen, Hongyu; Zhou, Fang; Liu, Qi] Hunan Agr Univ, Natl Res Ctr Engn Technol Utilizat Funct Ingredien, Collaborat Innovat Ctr Utilisat Funct Ingredients, Changsha 410128, Hunan, Peoples R China.
[Zhang, Yangbo; Liu, Changwei; Liu, Zhonghua; Zhang, Sheng; Zhou, Jinghui; Huang, Jianan; Chen, Hongyu; Zhou, Fang; Liu, Qi] Hunan Agr Univ, Coinnovat Ctr Educ, Minist Utilizat Bot Funct Ingredients, Changsha 410128, Hunan, Peoples R China.
[Liu, Changwei; Liu, Zhonghua; Huang, Jianan] Hunan Agricultrual Univ, Key Lab Evaluat & Utilizat Gene Resources Hort Cro, Minist Agr & Rural Affairs China, Changsha 410128, Peoples R China.
[Liu, Ailing] Hunan Agr Univ, Coll Biosci & Biotechnol, Changsha 410128, Hunan, Peoples R China.
通讯机构:
[Sheng Zhang; Jianan Huang; Zhonghua Liu] K
Key Laboratory of Tea Science of Ministry of Education, Hunan Agricultural University, Changsha 410128, Hunan, China<&wdkj&>National Research Center of Engineering Technology for Utilization of Functional Ingredients from Botanicals, Collaborative Innovation Centre of Utilisation of Functional Ingredients from Botanicals and Co-Innovation Center of Education Ministry for Utilization of Botanical Functional Ingredients, Hunan Agricultural University, Changsha 410128, Hunan, China<&wdkj&>Key Laboratory for Evaluation and Utilization of Gene Resources of Horticultural Crops, Ministry of Agriculture and Rural Affairs of China, Hunan Agricultrual University, Changsha 410128, China<&wdkj&>Key Laboratory of Tea Science of Ministry of Education, Hunan Agricultural University, Changsha 410128, Hunan, China<&wdkj&>National Research Center of Engineering Technology for Utilization of Functional Ingredients from Botanicals, Collaborative Innovation Centre of Utilisation of Functional Ingredients from Botanicals and Co-Innovation Center of Education Ministry for Utilization of Botanical Functional Ingredients, Hunan Agricultural University, Changsha 410128, Hunan, China
语种:
英文
关键词:
theaflavin;muscle inflammation;transcriptome;toll-like receptor;IL-6
期刊:
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
ISSN:
0021-8561
年:
2022
卷:
70
期:
41
页码:
13233-13250
基金类别:
National Key RD Project; Key R&D Project of Hunan Province; Opening Fund of Tea Refining and Innovation Key Laboratory of Sichuan Province; [2022YFE0111200]; [2021YFD1601104]; [2020NK2030]; [2020WK2017]; [SCTOF202201]
机构署名:
本校为第一机构
院系归属:
园艺园林学院
生物科学技术学院
摘要:
Persistent inflammatory infiltration of skeletal muscle is a principal trigger for the loss of muscle mass and strength. Theaflavins, the main functional components of black tea, have effects on muscle health, but their biological effects on skeletal muscle inflammation are unclear. We constructed in vitro and in vivo models of muscle inflammation and found that theaflavins reduced the expression of inflammatory factors (IL-1β, IL-6, and TNF-α) by regulating the TLR4/MyD88/NF-κB signaling pathway to alleviate muscle inflammation. In addition...

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