Enteromorpha prolifera polysaccharide-zinc complex modulates the immune response and alleviates LPS-induced intestinal inflammation via inhibiting the TLR4/NF-κB signaling pathway

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成果类型：

期刊论文

作者：

Zhang, Yumei;Duan, Xinyi;Wassie, Teketay;Wang, Hai-Hua;Li, Tiejun;...

通讯作者：

Xie, Chunyan

作者机构：

[Duan, Xinyi; Zhang, Yumei; Xie, Chunyan] Hunan Agr Univ, Coll Resources & Environm, Coll Biosci & Biotechnol, Changsha 410128, Hunan, Peoples R China.

[Wu, Xin; Wassie, Teketay; Li, Tiejun; Duan, Xinyi; Zhang, Yumei] Chinese Acad Sci, Inst Subtrop Agr, CAS Key Lab Agroecol Proc Subtrop Reg, Changsha 410125, Hunan, Peoples R China.

[Wu, Xin; Wassie, Teketay; Li, Tiejun; Duan, Xinyi; Zhang, Yumei] Natl Engn Lab Pollut Control & Waste Utilizat Liv, Changsha 410125, Hunan, Peoples R China.

[Wang, Hai-Hua] Qingdao Seawin Biotech Grp Co Ltd, Qingdao 266071, Peoples R China.

[Wu, Xin] Chinese Acad Sci, Tianjin Inst Ind Biotechnol, Tianjin 300308, Peoples R China.

通讯机构：

[Xie, Chunyan] H

Hunan Agr Univ, Coll Resources & Environm, Coll Biosci & Biotechnol, Changsha 410128, Hunan, Peoples R China.

语种：

英文

期刊：

FOOD & FUNCTION

ISSN：

2042-6496

年：

2022

卷：

期：

页码：

52-63

DOI：

10.1039/d1fo02171k

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [31902196]; Natural Science Foundation of Hunan ProvinceNatural Science Foundation of Hunan Province [2019JJ50268]; China Postdoctoral Science FoundationChina Postdoctoral Science Foundation [2019M662273]

机构署名：

本校为第一且通讯机构

院系归属：

资源环境学院

生物科学技术学院

摘要：

Enteromorpha prolifera polysaccharide-zinc (EP-Zn), a kind of polysaccharide-zinc complex, has been shown to improve the immune response and reduce the inflammatory factors in weaned piglets. Yet, the molecular mechanism remains unclear. The present study was conducted to investigate the immunomodulating activity and anti-inflammatory mechanism of EP-Zn in mice. Different doses (350 mg kg-1, 700 mg kg-1, 1050 mg kg-1 and 1400 mg kg-1) of EP-Zn were administered to C57BL/6J mice for 28 days. The results showed that under physiological conditions...

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Enteromorpha prolifera polysaccharide-zinc complex modulates the immune response and alleviates LPS-induced intestinal inflammation via inhibiting the TLR4/NF-κB signaling pathway

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