Integrative Genomics and Phenotypic Profiling Reveal Lacticplantibacillus plantarum BGI-N6 as a Multifunctional Candidate for Dermatological Probiotic Development.

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成果类型：

期刊论文

作者：

Jinhong Wang;Xiaowei Xu;Yangfeng Wen;Benliang Wei;Junke Chen;...

通讯作者：

Yiyi Zhong<&wdkj&>Yuanqiang Zou

作者机构：

[Jinhong Wang; Sihang Cai; Junke Chen; Zhinan Wu; Mengmeng Wang; Yangfeng Wen] BGI Research, Shenzhen, China

[Junke Chen] College of Life Sciences, South China Normal University, Guangzhou, China

[Sihang Cai] College of Pharmacy, Shenzhen Technology University, Shenzhen, China

[Yangfeng Wen] College of Plant Protection, Hunan Agricultural University, Changsha, China

Shenzhen Engineering Laboratory of Detection and Intervention of Human Intestinal Microbiome, BGI Research, Shenzhen, China

通讯机构：

[Yiyi Zhong] B

[Yuanqiang Zou] S

Shenzhen Engineering Laboratory of Detection and Intervention of Human Intestinal Microbiome, BGI Research, Shenzhen, China<&wdkj&>State Key Laboratory of Genome and Multi-Omics Technologies, BGI Research, Shenzhen, China<&wdkj&>BGI Precision Nutrition, Shenzhen, China

语种：

英文

关键词：

Lactiplantibacillus plantarum;antioxidant activity;complete genome;enzyme activity inhibition;phenotypic analysis;skin health

期刊：

FASEB JOURNAL

ISSN：

0892-6638

年：

2025

卷：

期：

页码：

e70979

DOI：

10.1096/fj.202501440R

基金类别：

This work was supported by National Natural Science Foundation of China under Grant Agreement, KCXFZ20240903094006009 : CY20241202124801003. Yuanqiang Zou will handle the correspondence of the article at all stages of the review and publication process, as well as postpublication. Jinhong Wang and Xiaowei Xu contributed equally to this work.

机构署名：

本校为其他机构

院系归属：

植物保护学院

摘要：

Probiotics and postbiotics are recognized for their potential to benefit skin health, and complete genome analysis serves as a pivotal tool to accelerate the exploration of probiotic functionalities. To investigate this relationship, this study aimed to elucidate the skin-promoting potential of Lactiplantibacillus plantarum BGI-N6 (BGI-N6) through integrated genomic analysis and phenotypic analysis. Results indicated that the high-precision complete genome of BGI-N6 comprises 3 257 641 bases with a 45% GC content and 3030 CDSs, involving mult...

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Integrative Genomics and Phenotypic Profiling Reveal Lacticplantibacillus plantarum BGI-N6 as a Multifunctional Candidate for Dermatological Probiotic Development.

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