期刊论文

Xie, Guang-rong

英文

Psychiatry Research

0165-1781

2014

220

3

874-882

10.1016/j.psychres.2014.08.056

National Natural Science Foundation of China [81371492, 81088001, 31100747]; Chinese Society of Academic Degrees and Graduate Education [2013Y13]; "Strategic Priority Research Program (B)" of the Chinese Academy of Sciences [XDB02030002]; Knowledge Innovation Project of the Chinese Academy of Sciences [KSCX2-EW-J-8]

本校为其他机构

Anhedonia is a hallmark symptom of major depressive disorder (MDD). Preliminary findings suggest that anhedonia is characterized by reduced reward anticipation and motivation of obtaining reward. However, relatively little is known about reward-based decision-making in depression. We tested the hypothesis that anhedonia in MDD may reflect specific impairments in motivation on reward-based decision-making and the deficits might be associated with depressive symptoms severity. In study 1, individuals with and without depressive symptoms performed the modified version of the Effort Expenditure for Rewards Task (EEfRT), a behavioral measure of cost/benefit decision-making. In study 2, MDD patients, remitted MDD patients and healthy controls were recruited for the same procedures. We found evidence for decreased willingness to make effort for rewards among individuals with subsyndromal depression; the effect was amplified in MDD patients, but dissipated in patients with remitted depression. We also found that reduced anticipatory and consummatory pleasure predicted decreased willingness to expend efforts to obtain rewards in MDD patients. For individuals with subsyndromal depression, the impairments were correlated with anticipatory anhedonia but not consummatory anhedonia. These data offer novel evidence that motivational deficits in MDD are correlated with depression severity and predicted by self-reported anhedonia. (C) 2014 Elsevier Ireland Ltd. All rights reserved.