This work was funded by the Project of Qinghai Science and Technology Department (2018-ZJ-924Q), the National Natural Science Foundation of China (82160800), Natural Science Foundation of Sichuan Province (2022NSFSC1321), the Doctoral Research Startup Fund of Affiliated Hospital of Southwest Medical University (19063), Luzhou Municipal Government - Southwest Medical University Cooperation Application Foundation (2021LZXNYD-J01) and Southwest Medical University applied basic research project