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Flavonoids from Rhododendron nivale Hook. f delay aging via modulation of gut microbiota and glutathione metabolism

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成果类型:
期刊论文
作者:
Guo, Xiao;Dong, Zhen;Li, Qien;Wan, Digao;Zhong, Jiangbin;...
通讯作者:
Meizhou Huang
作者机构:
[Li, Qien; Dongzhi, Duojie; Zhong, Jiangbin; Wan, Digao; Guo, Xiao] Qinghai Univ, Tibetan Medicial Coll, Tibetan Med Res Ctr, State Key Lab Tibetan Med Res & Dev, Xining 810016, Qinghai, Peoples R China.
[Huang, Meizhou] Affiliated Hosp Southwest Med Univ, Acad Expert Workstat Sichuan Prov, Luzhou 646000, Peoples R China.
[Dong, Zhen] Hunan Agr Univ, Coll Vet Med, Changsha 410128, Peoples R China.
通讯机构:
[Meizhou Huang] A
Academician (Expert) Workstation of Sichuan Province, The Affiliated Hospital of Southwest Medical University, Luzhou 646000, China
语种:
英文
关键词:
Anti-aging;Flavonoids;Intestinal flora;Metabolomics;Rhododendron nivale
期刊:
Phytomedicine
ISSN:
0944-7113
年:
2022
卷:
104
页码:
154270
基金类别:
This work was funded by the Project of Qinghai Science and Technology Department (2018-ZJ-924Q), the National Natural Science Foundation of China (82160800), Natural Science Foundation of Sichuan Province (2022NSFSC1321), the Doctoral Research Startup Fund of Affiliated Hospital of Southwest Medical University (19063), Luzhou Municipal Government - Southwest Medical University Cooperation Application Foundation (2021LZXNYD-J01) and Southwest Medical University applied basic research project
机构署名:
本校为其他机构
院系归属:
动物医学院
摘要:
BACKGROUND: Rhododendron nivale Hook. f (R.n), one of the four Manna Stash used in Tibetan medicine to delay aging, possesses anti-aging pharmacological activity. However, which R.n ingredients contain anti-aging properties and the underlying mechanisms involved are unclear. HYPOTHESIS/PURPOSE: Based on interactions between gut microbiota and natural medicines and the important role of gut microbiota in anti-aging, the study investigated the hypothesis that R.n possesses anti-aging properties and the interaction of gut microbiota with R.n is re...

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