Anti-melanogenic effects of epigallocatechin-3-gallate (EGCG), epicatechin-3-gallate (ECG) and gallocatechin-3-gallate (GCG) via down-regulation of cAMP/CREB /MITF signaling pathway in B16F10 melanoma cells

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Zhang, Xiangna;Li, Juan;Li, Yinhua;Liu, Zhonghua;Lin, Yong*;...

通讯作者：

Lin, Yong;Huang, Jian-an

作者机构：

[Huang, Jian-an; Li, Yinhua; Zhang, Xiangna; Liu, Zhonghua; Lin, Yong; Li, Juan; Lin, Y; Huang, JA] Hunan Agr Univ, Key Lab Tea Sci, Minist Educ, Changsha 410128, Hunan, Peoples R China.

[Huang, Jian-an; Li, Yinhua; Liu, Zhonghua; Lin, Yong; Li, Juan] Hunan Agr Univ, Natl Res Ctr Engn Technol Utilizat Funct Ingredie, Changsha, Peoples R China.

[Huang, Jian-an; Li, Yinhua; Liu, Zhonghua; Lin, Yong; Li, Juan] Hunan Agr Univ, Collaborat Innovat Ctr Utilizat Funct Ingredients, Changsha, Peoples R China.

通讯机构：

[Lin, Y; Huang, JA] H

Hunan Agr Univ, Key Lab Tea Sci, Minist Educ, Changsha 410128, Hunan, Peoples R China.

语种：

英文

关键词：

B16F10 cells;Melanin;Melanogenesis;Tea catechins;Tyrosinase

期刊：

Fitoterapia

ISSN：

1971-551X

年：

2020

卷：

145

页码：

104634

DOI：

10.1016/j.fitote.2020.104634

基金类别：

This work was supported by the National Major R & D Project in China (grant number: 2017YFD0400803 ) and the China Tea Research System Project (grant number: CARS19-09B ) and Scientific Research Fund of Hunan Provincial Education Department ( 19A223 ).

机构署名：

本校为第一且通讯机构

院系归属：

园艺园林学院

摘要：

Tea catechins, the main bioactive polyphenols in green tea, are well known for their health promoting effects. Previous studies have shown that gallocatechin-3-gallate (GCG), epigallocatechin-3-gallate (EGCG) and epicatechin-3-gallate (ECG) exerted strong inhibitory effects on mushroom tyrosinase activity in vitro, whilst EGCG inhibited melanogenesis in vivo, yet the underlying mechanisms are not entirely clear. In this study, we (i) evaluated and compared the inhibitory effects of the main tea catechins (GCG, EGCG, and ECG) on melanogenesis in B16F10 melanoma cells, and (ii) explain the under...

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Anti-melanogenic effects of epigallocatechin-3-gallate (EGCG), epicatechin-3-gallate (ECG) and gallocatechin-3-gallate (GCG) via down-regulation of cAMP/CREB /MITF signaling pathway in B16F10 melanoma cells

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