期刊论文

中文

食品科学

1002-6630

2011

32

19

232-235

湖南省人事厅湖南省博士后基金项目（0971111）；

本校为第一机构

目的：探讨灵芝孢子油对D-半乳糖所致衰老模型小鼠抗衰老作用及其作用机理。方法：以D-半乳糖建立小鼠衰老模型,灌胃灵芝孢子油900mg/（kg.d）45d后,检测小鼠血清中血清超氧化物歧化酶（SOD）、过氧化氢酶（CAT）活性;检测脾脏指数、胸腺指数;半定量PCR检测脾脏、胸腺中C3、P21 mRNA表达。结果：DB组（D-半乳糖＋灵芝孢子油）SOD、CAT的活性显著高于DY组（D-半乳糖＋玉米油）（P≤0.01）,DB组脾脏指数、胸腺指数显著高于DY组（P≤0.05）。C3mRNA在脾脏、胸腺中的表达DB组显著高于DY组（P≤0.05）,C3mRNA在胸腺中的表达SB组（生理盐水＋灵芝孢子油）高于SY组（生理盐水＋玉米油）（P≤0.05）;P21...

Objective： To explore the immunoregulation effect of Ganoderma lucidum spore oil in aged mouse models induced by D-galactose and its anti-aging mechanisms.Methods： Aged mice were intragastrically administered with Ganoderma lucidum spore oil for 45 consecutive days to examine the change of SOD activity,CAT activity,spleen index and thoracic gland index.Meanwhile,the mRNA expression levels of C3 and P21 in mouse spleen and thymus were determined by semi-quantitative RT-PCR.Results： The SOD activity and CAT activity in DB（D-galactose ＋ Ganod...