期刊论文

中文

食品科学

1002-6630

2014

35

1

224-228

10.7506/spkx1002-6630-201401044

科技部国际科技合作项目（2009DFA32350）；

本校为第一机构

目的:研究米糠植物甾醇对非酒精性脂肪性肝炎(non-alcoholicsteatohepatitis,NASH)大鼠的干预治疗作用。方法:实验选用50只健康SD雄性大鼠,随机分为正常对照组、NASH模型组和米糠甾醇低、中、高3个剂量组(65、130、195mg/kg)。高脂饲料饲喂造模,各实验组同时进行米糠甾醇溶液灌胃干预。13周后观察各组大鼠肝组织病理学特点,测定血清中血脂总胆固醇、甘油三酯、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇含量和谷丙转氨酶、谷草转氨酶、一氧化氮合酶和超氧化物歧化酶活性,并比较各组肝脏指数和脾脏指数。结果:肝脏组织切片观察到NASH模型组有明显的肝细胞脂肪变性和炎症聚集浸润,米糠甾醇各治疗组肝...

Aim： To investigate the effect of rice bran sterol （RBS） on non-alcoholic steatohepatitis （NASH） in Sprague-Dawley （SD） rats caused by feeding high-fat diet for 13 weeks. Methods： Totally 50 male SD rats were randomly assigned to control group, NASH group and three RBS treatment groups at doses of 65, 130 mg/kg and 195 mg/kg. The NASH group and RBS treatment groups were fed with high-fat diet and the RBS groups were administered with RBS by gavage at the same time. Two percent Tween-80 was added to improve the solubility of RBS. After f...