期刊论文

Protective Effect of Betulinic Acid on Cyclophosphamide-Induced Liver Injury in Mice

中文

食品科学

1002-6630

2020

41

21

147-153

10.7506/spkx1002-6630-20191028-312

湖南省教育厅重点项目(17A098) 湖南省研究生创新基金项目(CX2018B411) 湖南农业大学“双一流”学科建设项目(SYL2019049) 湖南省发展与改革委员会创新研发项目(37)。

本校为第一机构

为了探究桦木酸(betulinic acid,BA)对环磷酰胺(cyclophosphamide,CYP)导致的肝脏损伤的影响。将50只昆明小鼠随机分为5个组,即空白组、CYP组以及BA低、中、高剂量组。空白组和CYP组用1%(质量分数,下同)的可溶性淀粉灌胃,而其余各组按0.25、0.50、1.00 mg/kg m_b BA剂量混悬在1%可溶性淀粉糊中灌胃,连续灌胃14 d后,除空白组腹腔注射生理盐水外,其余各组连续2 d腹腔注射CYP(50 mg/kg m_b)诱导肝损伤模型。检测血清中谷丙转氨酶(alanine aminotransferase,ALT)和谷草转氨酶(aspartate aminotransferase,AST)活力;检测肝脏超氧化物歧化酶(superoxide dismutase,SOD)、谷胱甘肽过氧化物酶(glutathio...

The objective of this study was to evaluate the preventive effect of betulinic acid (BA) on cyclophosphamide (CYP)-induced liver injury in mice. Fifty male healthy Kunming mice were randomly divided into 5 groups including control, CYP, and low-, medium- and high-dose BA groups. The mice from the control and CYP groups were administered orally with 1% starch solution, and those from the other groups with BA at doses of 0.25, 0.50 and 1.00 mg/kg m_b for 14 days. Afterwards liver injury was induced by intraperitoneal injection of CYP at a dose of...