期刊论文

Effect of Pingyang Yellow Tea on Intestinal Barrier and Intestinal Flora in Rats Fed High-Fat Diet

中文

食品科学

1002-6630

2021

42

23

170-181

10.7506/spkx1002-6630-20201021-205

“十三五”国家重点研发计划重点专项（2017YFD0400803）； 财政部和农业农村部：现代农业产业技术体系建设专项（CARS-19-09B）；

本校为第一机构

为探讨‘平阳黄汤’对高脂饮食大鼠的肥胖调控作用及其与肠道屏障和菌群的关系,将SD雄性大鼠分为正常饮食组、高脂饮食组以及平阳黄汤低、中、高剂量组(75、150、300 mg/kg mb),建立预防肥胖模型。通过分析大鼠体质量变化、摄食量、脂肪指数、血清指标、肝脏指标和肝脏、结肠组织切片评估‘平阳黄汤’对高脂饮食大鼠的肥胖调控作用;通过分析肠道的病理形态、杯状细胞数量和紧密连接蛋白的表达评估肠道屏障作用;通过分析微生物多样性和菌群结构评估对肠道菌群的影响。结果:高剂量‘平阳黄汤’能极显著降低高脂饮食大鼠的体质量增长量、附睾和肾周脂肪质量(P

This study was intended to explore the regulatory effect of Pingyang yellow tea on high-fat diet(HDF)-induced obesity in rats and its relationship with the intestinal barrier and flora. SD male rats were divided into five groups: normal diet(ND),HFD,and low-,medium-and high-dose tea infusion(75,150 and 300 mg/kg mb). The regulatory effect of Pingyang yellow tea on obesity was evaluated by analyzing the body mass changes,feed intake,visceral fat indexes,serum biochemical indexes,liver lipids and liver and colon tissue sections of rats. The intes...