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Pharmacological and Pathological Effects of Mulberry Leaf Extract on the Treatment of Type 1 Diabetes Mellitus Mice

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成果类型:
期刊论文
作者:
Luo, Liru;Fan, Wei;Qin, Jingping;Guo, Shiyin;Xiao, Hang;...
通讯作者:
Tang, ZH
作者机构:
[Luo, Liru; Xiao, Hang; Tang, Zhonghai; Fan, Wei; Guo, Shiyin] Hunan Agr Univ, Coll Food Sci & Technol, Changsha 410128, Peoples R China.
[Luo, Liru; Xiao, Hang; Qin, Jingping; Tang, Zhonghai; Fan, Wei; Guo, Shiyin] Hunan Engn Technol Res Ctr Rapeseed Oil Nutr Hlth, Changsha 410128, Peoples R China.
[Qin, Jingping] Hunan Agr Univ, Coll Biosci & Biotechnol, Changsha 410128, Peoples R China.
通讯机构:
[Tang, ZH ] H
Hunan Agr Univ, Coll Food Sci & Technol, Changsha 410128, Peoples R China.
Hunan Engn Technol Res Ctr Rapeseed Oil Nutr Hlth, Changsha 410128, Peoples R China.
语种:
英文
关键词:
mulberry leaf extract;type 1 diabetes mellitus;biochemical parameters;metformin;pharmacological effect;pathological effect
期刊:
CURRENT ISSUES IN MOLECULAR BIOLOGY
ISSN:
1467-3037
年:
2023
卷:
45
期:
7
页码:
5403-5421
基金类别:
This work was supported by the Natural Science Foundation of Hunan Province, China (No. 2022JJ30295), the Scientific Research Fund of Hunan Provincial Education Department, China (Grant No. 18A108), the Major Research plan of the Changsha (No. kq1801016).
机构署名:
本校为第一且通讯机构
院系归属:
食品科学技术学院
生物科学技术学院
摘要:
This study investigated the pharmacological and pathological effects of aqueous mulberry leaf extract on type 1 diabetes mellitus mice induced with an intraperitoneal injection of streptozotocin (STZ). Diabetic mice were randomized into six groups: control (normal group), model, metformin-treated mice, and high-dose, medium-dose, and low-dose mulberry. The mulberry-treated mice were divided into high-, medium-, and low-dose groups based on the various doses of aqueous mulberry leaf extract during gavage. The efficacy of the six-week interventio...

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