Characterization of Blebbistatin Inhibition of Smooth Muscle Myosin and Nonmuscle Myosin-2

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成果类型：

期刊论文

作者：

Zhang, Hai-Man;Ji, Huan-Hong;Ni, Tong;Ma, Rong-Na;Wang, Aibing;...

通讯作者：

Li, Xiang-dong

作者机构：

[Ji, Huan-Hong; Ni, Tong; Li, Xiang-dong; Zhang, Hai-Man; Ma, Rong-Na] Chinese Acad Sci, Inst Zool, State Key Lab Integrated Management Pest Insects, Grp Cell Motil & Muscle Contract, Beijing 100101, Peoples R China.

[Ni, Tong; Li, Xiang-dong; Zhang, Hai-Man] Univ Chinese Acad Sci, Beijing 100049, Peoples R China.

[Wang, Aibing] Hunan Agr Univ, RCRV, Coll Vet Med, LAMFG, Changsha 410128, Hunan, Peoples R China.

[Ma, Rong-Na] Shanghai Jiao Tong Univ, Sch Med, Fac Publ Hlth, Hongqiao Int Inst Med,Shanghai Tongren Hosp, Shanghai 200025, Peoples R China.

[Li, Xiang-dong] Chinese Acad Sci, Inst Zool, Beijing 100101, Peoples R China.

通讯机构：

[Li, Xiang-dong] C

Chinese Acad Sci, Inst Zool, Beijing 100101, Peoples R China.

语种：

英文

期刊：

BIOCHEMISTRY

ISSN：

0006-2960

年：

2017

卷：

期：

页码：

4235-4243

DOI：

10.1021/acs.biochem.7b00311

基金类别：

National Basic Research Program of ChinaNational Basic Research Program of China [2013CB932802]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [31470791, 31672359, 31571432]; Hunan Provincial Natural Science Foundation of ChinaNatural Science Foundation of Hunan Province [2015JC3097]

机构署名：

本校为其他机构

院系归属：

动物医学院

摘要：

Blebbistatin is a potent and specific inhibitor of the motor functions of class II myosins, including striated muscle myosin and nonmuscle myosin-2 (NM2). However, the blebbistatin inhibition of NM2c has not been assessed and remains controversial with respect to its efficacy with smooth muscle myosin (SmM), which is highly homologous to NM2. To clarify these issues, we analyzed the effects of blebbistatin on the motor activities of recombinant SmM and three NM2s (NM2a, -2b, and -2c). We found that blebbistatin potently inhibits the actin-activ...

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Characterization of Blebbistatin Inhibition of Smooth Muscle Myosin and Nonmuscle Myosin-2

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