期刊论文

Li, XW

英文

Journal of Dairy Science

0022-0302

2023

106

10

7266-7280

10.3168/jds.2023-23366

National Natural Science Foundation of China (Beijing, China) [32273090]; science and technology innova-tion program of Hunan Province (Changsha, China) [2022RC1161, 2021RC4060]; science fund for distinguished young scholars of Changsha City, China (Changsha, China) [kq2206033]; Natural Science Foundation of Hunan (Changsha, China) [2022JJ40169]; Research Foundation of Education Bureau of Hunan Province (Changsha, China) [21A0133]

本校为第一机构

Ketosis is often accompanied by a reduction in milk production in dairy cows, but the molecular mechanism has not been fully elucidated. Ketotic cows possess systemic oxidative stress (OS), which may implicate apoptosis in mammary glands. Sirtuin 3 (SIRT3) is a vital regulator of cellular redox homeostasis and is under the control of AMP-activated protein kinase (AMPK) signaling in nonruminants. Thus, we aimed to investigate (1) the AMPK-SIRT3 and apoptosis status of mammary glands from ketotic cows, (2) the effect of SIRT3 on OS-induced apopto...