DADS Inhibits the Proliferation of MDCC-MSB-1 Cells by Inducing Autophagy via the MEK/ERK Signalling Pathway

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Pan, Yanying;Liu, Jianying;Wang, Dongliang;Zhou, Pengfei;Chen, Tao;...

通讯作者：

Ji, CX

作者机构：

[Wang, Dongliang; Pan, Yanying; Liu, Jianying; Ji, Chunxiao; Chen, Tao; Zhou, Pengfei; Ji, CX] Hunan Agr Univ, Coll Vet Med, Changsha 410128, Peoples R China.

[Wang, Dongliang; Pan, Yanying; Liu, Jianying; Ji, Chunxiao; Chen, Tao; Zhou, Pengfei; Ji, CX] Hunan Agr Univ, Hunan Engn Technol Res Ctr Vet Drugs, Changsha 410128, Peoples R China.

[Tang, Yulong] Chinese Acad Sci, Inst Subtrop Agr, Changsha 410125, Hunan, Peoples R China.

通讯机构：

[Ji, CX ] H

Hunan Agr Univ, Coll Vet Med, Changsha 410128, Peoples R China.

Hunan Agr Univ, Hunan Engn Technol Res Ctr Vet Drugs, Changsha 410128, Peoples R China.

语种：

英文

关键词：

DADS;MDCC-MSB-1 cells;Autophagy;MEK;ERK

期刊：

Cell Biochemistry and Biophysics

ISSN：

1085-9195

年：

2024

卷：

期：

页码：

271-278

DOI：

10.1007/s12013-023-01214-4

基金类别：

The Hunan Provincial Department of Education (Grant No. 22A0164) provided funding for this work.

机构署名：

本校为第一且通讯机构

院系归属：

动物医学院

摘要：

Diallyl disulfide (DADS) is effective at suppressing tumour cell growth and proliferation. This study verified the morphology and growth activity of MDCC-MSB-1 cells by using an MTT assay to detect the effect of DADS on the proliferation of MDCC-MSB-1 cells and a CCK8 assay to detect the effect of DADS on the viability and proliferation of MDCC-MSB-1 cells. We found that the viability and proliferation of MDCC-MSB-1 cells decreased with increasing DADS concentrations. MDC staining and Western blotting were used to analyse autophagy, the associated protein LC3 and the MEK/ERK pathway proteins M...

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DADS Inhibits the Proliferation of MDCC-MSB-1 Cells by Inducing Autophagy via the MEK/ERK Signalling Pathway

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