Enhanced Antiarthritic Efficacy by Nanoparticles of (-)-Epigallocatechin Gallate-Glucosamine-Casein

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成果类型：

期刊论文

作者：

Zheng, Yafang;Xiao, Lizheng;Yu, Chenhuan;Jin, Peng;Qin, Dingkui;...

通讯作者：

Du, Qizhen;Liu, Zhonghua

作者机构：

[Du, Qizhen; Qin, Dingkui; Zheng, Yafang; Jin, Peng] Zhejiang A&F Univ, Coll Agr & Food Sci, Key Lab Qual Improvement Agr Prod Zhejiang Prov, Linan 311300, Peoples R China.

[Liu, Zhonghua; Xiao, Lizheng] Hunan Agr Univ, Natl Res Ctr Engn Technol Utilizat Bot Funct Ingr, Key Lab Educ Minist Tea Sci, Changsha 410128, Hunan, Peoples R China.

[Yu, Chenhuan] Zhejiang Acad Med Sci, Expt Anim Ctr, Hangzhou 310013, Zhejiang, Peoples R China.

[Yin, Junfeng; Xu, Yongquan] Minist Agr, Key Lab Tea Biol & Resources Utilizat, Chinese Acad Agr Sci, Tea Res Inst, 9 South Meiling Rd, Hangzhou 310008, Zhejiang, Peoples R China.

通讯机构：

[Du, Qizhen] Z

[Liu, Zhonghua] H

Zhejiang A&F Univ, Coll Agr & Food Sci, Key Lab Qual Improvement Agr Prod Zhejiang Prov, Linan 311300, Peoples R China.

Hunan Agr Univ, Natl Res Ctr Engn Technol Utilizat Bot Funct Ingr, Key Lab Educ Minist Tea Sci, Changsha 410128, Hunan, Peoples R China.

语种：

英文

关键词：

(-)-epigallocatechin gallate;arthritis;caseins;glucosamine;nanoparticle

期刊：

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

ISSN：

0021-8561

年：

2019

卷：

期：

页码：

6476-6486

DOI：

10.1021/acs.jafc.9b02075

基金类别：

Key R&D Program Project of Zhejiang Province, China [2019C02072]; Fund for Distinguished Scholars of Zhejiang Agricultural and Forestry University [2014FR064]; Key R&D Program Project of China [2017YFD0400803]; Zhejiang Innovation discipline titled with Laboratory Animal Genetic Engineering [201604]

机构署名：

本校为通讯机构

院系归属：

园艺园林学院

摘要：

This work aims to improve the antiarthritic activity of (-)-epigallocatechin gallate (EGCG) and glucosamine (GA) through fabrication and optimization of casein protein nanoparticles (EGC-NPs). Optimized EGC-NPs were obtained with a EGCG/GA/casein ratio of 1:2:8 (w/w/w). The EGC-NPs gave a mean size of 186 ± 3.5 nm and an entrapment efficiency of 86.8 ± 2.7%, and they exhibited a greater inhibitory activity against human fibroblast-like synoviocytes-osteoarthritis cells and human fibroblast-like synoviocytes-rheumatoid arthritis cells compared...

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Enhanced Antiarthritic Efficacy by Nanoparticles of (-)-Epigallocatechin Gallate-Glucosamine-Casein

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