期刊论文

Gui, Qing-Wen

英文

ACS OMEGA

2470-1343

2021

6

40

25940-25949

10.1021/acsomega.1c02645

This research was supported by the National Natural Science Foundation of China (31672457), the Hunan Province Science Foundation for Youths (2018JJ3215), the Research Foundation of Education Bureau of Hunan Province (18C0147), the Hunan Agricultural University Science Foundation for High-Level Personnel (17QN21), and the Double First-Class Construction Project of the Hunan Agricultural University (SYL2019064, SYL2019063 SYL201802003, YB2018007, and CX20190497).

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A novel metal catalyst-free and environmentally friendly method for the regioselective iodination of imidazo[1,2-α]pyridines at their C3 position is disclosed, which has a wide substrate scope and could be sustainable. This reaction proceeds through ultrasound acceleration in the presence of a green alcohol solvent. Compared with a conventional heating system, the reaction efficiency and the rate are significantly improved and the iodine atom economy is maximized using ultrasound techniques. ...