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Triclocarban exhibits higher adipogenic activity than triclosan through peroxisome proliferator-activated receptors pathways

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成果类型:
期刊论文
作者:
Zhang, Jia-Da;He, Sen;He, Ting-Ting;Li, Chuan-Hai;Yan, Bing-Hua;...
通讯作者:
Cao, LY
作者机构:
[Yan, Bing-Hua; He, Ting-Ting; Yang, Yuan; Yang, Jian; Zhang, Jia-Da; Cao, Lin-Ying; He, Sen; Cao, LY; Luo, Lin] Hunan Agr Univ, Coll Environm & Ecol, Changsha 410128, Peoples R China.
[Li, Chuan-Hai] Qingdao Univ, Sch Publ Hlth, 308 Ningxia Rd, Qingdao 266071, Peoples R China.
[Cao, Lin-Ying; Yin, Yu-Long] Hunan Agr Univ, Coll Anim Sci & Technol, Changsha 410128, Peoples R China.
通讯机构:
[Cao, LY ] H
Hunan Agr Univ, Coll Environm & Ecol, Changsha 410128, Peoples R China.
语种:
英文
关键词:
Antimicrobial agents;Lipid metabolism;Molecular mechanism;PPARs;Triclocarban;Triclosan
期刊:
Environmental Pollution
ISSN:
0269-7491
年:
2024
卷:
342
页码:
123030
基金类别:
National Postdoctoral Program for Innovative Talents [BX20200127]; China Postdoctoral Science Founda- tion [2020M682567]; National Natural Science Foundation of China [21906050, 42077380, 22176076]; Hunan Provincial Key R D [2023NK2029]
机构署名:
本校为第一且通讯机构
院系归属:
动物科学技术学院
摘要:
Previous epidemiological and animal studies have showed the lipid metabolic disruption of antimicrobial tri-clocarban (TCC) and triclosan (TCS). However, the present in vivo researches were mainly devoted to the hepatic lipid metabolism, while the evidence about the impacts of TCC/TCS on the adipose tissue is very limited and the potential mechanism is unclear, especially the molecular initiation events. Moreover, little is known about the toxic difference between TCC and TCS. This study aimed to demonstrate the differential adipogenic activity of TCC/TCS as well as the potential molecular mec...

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