期刊论文

Li, Yu-sheng;Li, Wen-ping

英文

BIOSCIENCE REPORTS

0144-8463

2018

38

1

BSR20171554.

10.1042/BSR20171554

This work was supported by the Provincial Science Foundation of Hunan [grant number 2015JJ3139 and grant number 2017JJ3499]; the Health and Family Planning Commission of Hunan Province [grant number B2014-12]; the Administration of Traditional Chinese Medicine of Hunan Province [grant number 2015116]; the China Scholarship Council [grant number 201606375101 and grant number 201606370164]; the Hunan Provincial Innovation Foundation for Postgraduate [grant number CX2016B060] and the Clinical and Rehabilitation Research Foundation of Xiangya Hospital and Weiming of Peking University [grant number xywm2015II04 and grant number xywm2015II07].

本校为通讯机构

Pain represents a major clinical problem and one which has exercised generations of healthcare professionals. Earthworms are used as a traditional Chinese medicine, and have been applied pharmacologically and clinically since a long time in China. However, the analgesic effects of earthworm extract (EE) are seldom studied. Hence, we evaluated the analgesic effects of EE in mice. The obtained data showed that EE increased pain threshold and exhibited peripheral but not central analgesic effects in mice; evidenced by increased inhibition ratio in acetic acid writhing test and formalin test, wher...