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Excitatory amino acid transporter supports inflammatory macrophage responses.

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成果类型:
期刊论文
作者:
Gan, Zhending;Guo, Yan;Zhao, Muyang;Ye, Yuyi;Liao, Yuexia;...
通讯作者:
Ren, Wenkai
作者机构:
[Guo, Yan; Liu, Bingnan; Gan, Zhending; Ye, Yuyi; Zhao, Muyang] State Key Laboratory of Swine and Poultry Breeding Industry, Guangdong Laboratory of Lingnan Modern Agriculture, College of Animal Science, South China Agricultural University, Guangzhou 510642, China
[Liao, Yuexia] School of Nursing & School of Public Health, Yangzhou University, Yangzhou 225009, China
[Yin, Jie] College of Animal Science and Technology, Hunan Agricultural University, Changsha 410128, China
[Zhou, Xihong; Yin, Yulong] Institute of Subtropical Agriculture, Chinese Academy of Sciences, Changsha 410125, China
[Yan, Yuqi] Department of Veterinary Medicine, College of Animal Sciences, Zhejiang University, Hangzhou 310058, China
通讯机构:
[Ren, Wenkai] S
State Key Laboratory of Swine and Poultry Breeding Industry, Guangdong Laboratory of Lingnan Modern Agriculture, College of Animal Science, South China Agricultural University, Guangzhou 510642, China. Electronic address:
语种:
英文
关键词:
Aspartate;Excitatory amino acid transporter;Glutamate;Macrophages;mTORC1
期刊:
科学通报(英文版)
ISSN:
2095-9273
年:
2024
机构署名:
本校为其他机构
院系归属:
动物科学技术学院
摘要:
Excitatory amino acid transporters (EAATs) are responsible for excitatory amino acid transportation and are associated with auto-immune diseases in the central nervous system and peripheral tissues. However, the subcellular location and function of EAAT2 in macrophages are still obscure. In this study, we demonstrated that LPS stimulation increases expression of EAAT2 (coded by Slc1a2) via NF-κB signaling. EAAT2 is necessary for inflammatory macrophage polarization through sustaining mTORC1 activation. Mechanistically, lysosomal EAAT2 mediates...

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