Gynostemma pentaphyllum protects mouse male germ cells against apoptosis caused by zearalenone via Bax and Bcl-2 regulation

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成果类型：

期刊论文

作者：

Yuan, Hui;Deng, Youtian;Yuan, Liyun;Wu, Jing;Yuan, Zhihang;...

通讯作者：

He, Zuping

作者机构：

[Wu, Jing; Zhu, Li; Yuan, Liyun; Li, Rongfang; Yi, Jine; Wen, Lixin; Deng, Youtian; Guo, Chengzhi; Yuan, Hui; Yuan, Zhihang; Zhang, Ming] Hunan Agr Univ, Coll Vet Med, Changsha 410128, Hunan, Peoples R China.

[He, Zuping] Georgetown Univ, Med Ctr, Dept Biochem & Mol & Cellular Biol, Washington, DC 20057 USA.

[He, Zuping] Georgetown Univ, Med Ctr, Dept Biochem & Mol & Cellular Biol, 3900 Reservoir Rd,NW, Washington, DC 20057 USA.

通讯机构：

[He, Zuping] G

Georgetown Univ, Med Ctr, Dept Biochem & Mol & Cellular Biol, 3900 Reservoir Rd,NW, Washington, DC 20057 USA.

语种：

英文

关键词：

Gynostemma pentaphyllum;anti-toxicity;Zearalenone;male germ cells;Bax and Bcl-2

期刊：

Toxicology Mechanisms and Methods

ISSN：

1537-6516

年：

2010

卷：

期：

页码：

153-158

DOI：

10.3109/15376511003660185

基金类别：

Department of Education of Hunan Province, China [03A02000]

机构署名：

本校为第一机构

院系归属：

动物医学院

摘要：

The objective of this study was to explore the effects of Gynostemma pentaphyllum on Zearalenone-induced apoptosis in mouse male germ cells. Fifty Kunming male mice at 25-days-old were classified into five groups: group A was the control (10% ethanol, 0.5 ml/day); group B with 10 μg Zearalenone/day; group C with 10 μg Zearalenone and 50 mg/kg/day Gynostemma pentaphyllum; group D with 10 μg Zearalenone and 100 mg/kg/day Gynostemma pentaphyllum; and group E with 10 μg Zearalenone and 200 mg/kg/day Gynostemma pentaphyllum. It was found that Gy...

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Gynostemma pentaphyllum protects mouse male germ cells against apoptosis caused by zearalenone via Bax and Bcl-2 regulation

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