Optimal fasting duration for mice as assessed by metabolic status

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成果类型：

期刊论文

作者：

Fu, Jian;Liu, Sha;Li, Mengyao;Guo, Fangrui;Wu, Xiaoran;...

通讯作者：

Li, XW

作者机构：

[Li, Mengyao; Wu, Xiaoran; Hu, Jiahao; Wang, Ji; Li, XW; Wen, Lixin; Fu, Jian; Guo, Fangrui; Li, Xiaowen; Liu, Sha] Hunan Agr Univ, Coll Vet Med, Hunan Engn Res Ctr Livestock & Poultry Hlth Care, Changsha, Peoples R China.

[Li, XW; Li, Xiaowen] Cent South Univ, Xiangya Hosp 2, Natl Clin Res Ctr Metab Dis, Changsha, Peoples R China.

[Li, XW; Li, Xiaowen] Cent South Univ, Xiangya Hosp 2, Minist Educ, Dept Metab & Endocrinol,Key Lab Diabet Immunol, Changsha, Peoples R China.

[Li, XW; Li, Xiaowen] Cent South Univ, Xiangya Hosp 2, Metab Syndrome Res Ctr, Changsha, Peoples R China.

[Li, XW; Li, Xiaowen] Changsha Agr & Rural Affairs Bur, Anim Epidem Prevent Dept, Changsha, Peoples R China.

通讯机构：

[Li, XW ] H

Hunan Agr Univ, Coll Vet Med, Hunan Engn Res Ctr Livestock & Poultry Hlth Care, Changsha, Peoples R China.

Cent South Univ, Xiangya Hosp 2, Natl Clin Res Ctr Metab Dis, Changsha, Peoples R China.

Cent South Univ, Xiangya Hosp 2, Minist Educ, Dept Metab & Endocrinol,Key Lab Diabet Immunol, Changsha, Peoples R China.

Cent South Univ, Xiangya Hosp 2, Metab Syndrome Res Ctr, Changsha, Peoples R China.

语种：

英文

关键词：

Fasting duration;High-fat diet;Metabolic research;Mouse model;Nutritional research

期刊：

Scientific Reports

ISSN：

2045-2322

年：

2024

卷：

期：

页码：

21509

DOI：

10.1038/s41598-024-72695-3

基金类别：

Horizontal topics of Hunan agricultural University [2022xczx-414]; National Key R&D Program of China [2016YDF0501200]

机构署名：

本校为第一且通讯机构

院系归属：

动物医学院

摘要：

In the study of obesity and diabetes, mice are widely used for experimental research, and fasting is a common procedure used to reset metabolism in mouse models. The fasting duration for experimental mice varies greatly in nutritional and metabolic studies, ranging from 2 to 48h. This study aims to assess the optimal fasting duration for mice fed low- and high-fat diets over a short period of time. C57BL/6J mice were fed a low-fat diet (LFD) or high-fat diet (HFD) and fasted for 4, 6, 8, 10, 12, or 24h. The effects of different conditions after fasting on the metabolic level of mice were explo...

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Optimal fasting duration for mice as assessed by metabolic status

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