Accurate prediction of genes in genomes has always been a challenging task for bioinformaticians and computational biologists. Therefore, the discovery of relations in coding and non-coding sequences has led to new perspectives in the understanding of the DNA sequences. This has motivated us to find new methods to distinguish coding and non-coding sequences. We first introduce a number sequence representation of DNA sequences. Multi-affinity analysis and local Hölder exponent are then performed on the representation of the obtained number sequ...