The strategic interaction between the government and the public is the core of prevention and control of human infected with H7N9 subtype influenza virus. This paper studies the interaction between government departments and the public on prevention and control of the epidemic in the early stages of outbreak of H7N9 subtype influenza, and drew a game equilibrium strategy between the government and the public. Using the game equilibrium strategy to enrich SI diffusion model of infectious diseases, established H7N9 subtype influenza spread and di...